月经周期规律所需时间与健康风险。
Time to cycle regularity and health risks.
作者信息
Naveed Amna, Whooten Rachel
机构信息
Division of Pediatric Endocrinology, Massachusetts General Hospital, Boston, Massachusetts, USA.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2024 Dec 1;31(6):210-215. doi: 10.1097/MED.0000000000000881. Epub 2024 Sep 2.
PURPOSE OF REVIEW
Adolescents often have irregular menstrual cycles after menarche until the reproductive axis fully matures. This review explores how menstrual regularity is established and the health risks associated with prolonged time to cycle regularity in adolescents.
RECENT FINDINGS
Cross-sectional studies show an association between prolonged time to cycle regularity in adolescents and increased risks for ongoing menstrual dysfunction, cardiometabolic disorders, cancers, and overall mortality. Importantly, some of these cardiometabolic associations are independent of PCOS status.
SUMMARY
The menstrual cycle can be used as a vital sign for assessing overall health. While further longitudinal studies are needed to establish causal relationships, these findings highlight a crucial window for early intervention in adolescents with prolonged time to cycle regularity to mitigate future risks.
综述目的
青少年月经初潮后月经周期通常不规律，直至生殖轴完全成熟。本综述探讨了月经规律性是如何建立的，以及青少年月经周期规律时间延长所带来的健康风险。
最新发现
横断面研究表明，青少年月经周期规律时间延长与持续月经功能障碍、心血管代谢紊乱、癌症及全因死亡率增加之间存在关联。重要的是，其中一些心血管代谢方面的关联独立于多囊卵巢综合征状态。
总结
月经周期可作为评估整体健康的一项重要指标。虽然需要进一步的纵向研究来确立因果关系，但这些发现凸显了一个关键窗口期，即对月经周期规律时间延长的青少年进行早期干预，以降低未来风险。
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