Wu Tao, Xu Chenxiao, Tang Lu, Wu Xi, Peng Pengfei, Yue Xun, Cheng Wei, He Shuai, Li Lei, Chen Yucheng, Ren Yan, Sun Jiayu
Department of Radiology, West China Hospital, Sichuan University.
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University.
Exp Clin Endocrinol Diabetes. 2024 Sep 2;132(10):562-9. doi: 10.1055/a-2348-4468.
To assess the relationship between the left ventricular remodeling parameters of cardiac magnetic resonance and NT-pro-BNP in patients with primary aldosteronism (PA).
Seventy-four PA and 39 essential hypertension patients were prospectively recruited and underwent cardiac magnetic resonance. Plasma NT-pro-BNP was measured before patients underwent cardiac magnetic resonance. Left ventricular remodeling parameters were defined as left ventricular function parameters, T1 mapping parameters, and strain parameters. Differences in continuous variables between two groups were analyzed using Student's t-test or Mann-Whitney U test. Differences in categorical variables between two groups were analyzed by chi-squared test. Spearman's correlation and linear regression were used to analyze the relationships between left ventricular remodeling parameters and plasma NT-Pro-BNP level. P<0.05 was considered as statistically significant.
Patients with PA demonstrated higher NT-pro-BNP [86.0 (49.5, 145.5) vs. 45.0 (28.5, 73.5) pg/mL, P=0.001] and Native T1 (1227±41 vs. 1206±43 ms, P=0.015) level than essential hypertension patients. Compared to patients with normal NT-pro-BNP levels, those with abnormal levels demonstrated different left ventricular remodeling parameters. NT-pro-BNP level was independently related to native T1 (β=0.316, P=0.006), extracellular volume (β=0.419, P<0.001), short-axis global circumferential strain (β=0.429, P<0.001), four-chamber global longitudinal strain (β=0.332, P=0.002), and four-chamber global radial strain (β=-0.334, P=0.004) in patients after adjusting for baseline characteristics.
NT-pro-BNP level was related to left ventricular remodeling parameters derived from cardiac magnetic resonance in patients with PA. This result implies that clinicians should pay attention to NT-pro-BNP assessment in patients with PA in routine clinical assessment.
评估原发性醛固酮增多症（PA）患者心脏磁共振成像的左心室重构参数与N末端B型利钠肽原（NT-pro-BNP）之间的关系。
前瞻性纳入74例PA患者和39例原发性高血压患者，并进行心脏磁共振成像检查。在患者进行心脏磁共振成像检查前检测血浆NT-pro-BNP水平。左心室重构参数定义为左心室功能参数、T1 mapping参数和应变参数。两组间连续变量的差异采用Student's t检验或Mann-Whitney U检验进行分析。两组间分类变量的差异采用卡方检验进行分析。采用Spearman相关性分析和线性回归分析左心室重构参数与血浆NT-Pro-BNP水平之间的关系。P<0.05被认为具有统计学意义。
PA患者的NT-pro-BNP水平[86.0（49.5，145.5）vs. 45.0（28.5，73.5）pg/mL，P=0.001]和固有T1水平（1227±41 vs. 1206±43 ms，P=0.015）均高于原发性高血压患者。与NT-pro-BNP水平正常的患者相比，NT-pro-BNP水平异常的患者左心室重构参数不同。在校正基线特征后，NT-pro-BNP水平与固有T1（β=0.316，P=0.006）、细胞外容积（β=0.419，P<0.001）、短轴整体圆周应变（β=0.429，P<0.001）、四腔心整体纵向应变（β=0.332，P=0.002）和四腔心整体径向应变（β=-0.334，P=0.004）独立相关。
PA患者的NT-pro-BNP水平与心脏磁共振成像得出的左心室重构参数相关。这一结果提示临床医生在常规临床评估中应关注PA患者的NT-pro-BNP评估。
