NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Sesto Fiorentino, Florence, Italy.
Enzymes. 2024;55:193-212. doi: 10.1016/bs.enz.2024.06.007. Epub 2024 Jul 20.
Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variegate chemical classes, also of the natural origin. This contribution reports the main classes of compounds profiled in vitro on the bCAs and thus may be worth developing for the validation process of this class of enzymes.
非磺胺类化学基团能够抑制细菌（b）表达的碳酸酐酶（CA；EC 4.2.1.1），这是第 6 章中讨论的典型调节剂的重要替代物，因为它可以获得大量不同的化学类别，包括天然来源的化合物。本研究报告了体外研究的 bCA 主要化合物类别，因此这些化合物可能值得进一步开发，以验证该酶类别的有效性。
