Qi Shuang, Yuan Yuan, Yang Wen, Su Jing-Yang, Hao Li-Ying
Department of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,China.
Department of Pharmacy,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin,Jiangsu 214400,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2024 Aug;46(4):592-602. doi: 10.3881/j.issn.1000-503X.15789.
Alzheimer's disease (AD) is a common neurodegenerative disease with the main manifestations of progressive cognitive dysfunction,behavioral disorders,and gradual decline of living ability.The etiology of AD is complex,and the pathogenesis of this disease remains controversial.Calcium signaling plays an important role in regulating neuronal activities,including neurotransmitter release,synaptic plasticity,memory storage,and neuronal apoptosis.Increasing studies have shown that neuronal calcium dyshomeostasis is a major pathological factor in the occurrence and development of AD.This article reviews the role and research progress in intracellular calcium dyshomeostasis in AD,including the relationship between calcium homeostasis and amyloid β,the role of calcium/calmodulin-dependent protein kinases in tau phosphorylation,calcium signaling pathways,the relationship between calcium homeostasis and mitochondrial function,autophagy,and neuroinflammation.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，主要表现为进行性认知功能障碍、行为紊乱以及生活能力逐渐下降。AD的病因复杂，其发病机制仍存在争议。钙信号在调节神经元活动中起重要作用，包括神经递质释放、突触可塑性、记忆存储和神经元凋亡。越来越多的研究表明，神经元钙稳态失衡是AD发生发展的主要病理因素。本文综述了细胞内钙稳态失衡在AD中的作用及研究进展，包括钙稳态与淀粉样β蛋白的关系、钙/钙调蛋白依赖性蛋白激酶在tau蛋白磷酸化中的作用、钙信号通路、钙稳态与线粒体功能、自噬及神经炎症的关系。
