Goodman R E, Anderson D C, Bu'lock D E, Sheffield B, Lynch S S, Butt W R
Arch Sex Behav. 1985 Apr;14(2):141-6. doi: 10.1007/BF01541659.
This project was an attempt to test Dörner's theory that aspects of gender identity and sexual behavior depend on a defect in a normal imprinting mechanism of testicular testosterone (T) on the male hypothalamus. It has been suggested that such an action by T is incomplete in male-to-female transsexuals and that in this disorder the hypothalamus retains a cyclic pattern of gonadotrophin secretion and a positive feedback response to estrogens, such as is seen in the normal female. Five untreated male-to-female transsexuals and five normal male controls were each given 2 mg IM of estradiol, and T, estradiol, LH, and FSH globulin was measured serially over the following five days. No significant differences were found in the gonadotrophin or any of the other hormone responses in the transsexuals compared to normal controls. If there is a defect in imprinting of the hypothalamus in transsexual men, it does not seem to affect the basal levels of gonadotrophins or the pattern of their response to estrogen, at least in the intact male.
该项目旨在验证多纳的理论，即性别认同和性行为的某些方面取决于睾丸睾酮（T）对男性下丘脑正常印记机制存在缺陷。有人提出，T的这种作用在男变女的变性者中并不完整，在这种疾病中，下丘脑保留了促性腺激素分泌的周期性模式以及对雌激素的正反馈反应，就像正常女性那样。给5名未经治疗的男变女变性者和5名正常男性对照组每人肌肉注射2毫克雌二醇，并在接下来的五天内连续测量T、雌二醇、促黄体生成素（LH）和促卵泡生成素（FSH）球蛋白。与正常对照组相比，变性者的促性腺激素或任何其他激素反应均未发现显著差异。如果男变女的变性男性下丘脑存在印记缺陷，至少在完整男性中，这似乎不会影响促性腺激素的基础水平或其对雌激素的反应模式。
