激活暗基因组以照亮癌症疫苗靶点。
Activating the dark genome to illuminate cancer vaccine targets.
机构信息
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
出版信息
Nat Genet. 2024 Sep;56(9):1770-1771. doi: 10.1038/s41588-024-01850-3.
Abstract
Epigenetic therapy awakens myriad transposable elements to generate new antigens that could prime tumor cells for immunotherapy. A new study of glioblastoma discovers indiscriminate awakening in normal cells also and then presents a more selective strategy for potential therapeutic targeting.
摘要
表观遗传疗法唤醒了无数转座元件，产生新的抗原，从而使肿瘤细胞能够对免疫疗法产生反应。一项新的胶质母细胞瘤研究发现，正常细胞也会被不加区分地唤醒，然后提出了一种更具选择性的潜在治疗靶点策略。
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