Department of Critical Care Medicine, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 51900, Guangdong, China.
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
Lipids Health Dis. 2024 Sep 2;23(1):278. doi: 10.1186/s12944-024-02257-z.
The health effects of Life's Essential 8 (LE8) on chronic diseases have been disclosed, but its association with hypertension remains unknown. The current study aimed to explore the potential link between 10-year LE8 trajectory and the incidence of hypertension.
LE8 was constructed from four behaviors and four metabolic factors, ranging from 0 to 100. Latent mixture models were used to identify trajectories of LE8 scores during 2006 to 2016. Incident hypertension was diagnosed based on self-reported clinical diagnoses and physical examinations from 2016 to 2020. Cox models were employed to assess the association of LE8 trajectories with hypertension. In addition to incorporating the mean hs-CRP levels from 2006 to 2016, age, sex, monthly income, educational level, and occupation at recruitment were adjusted for as confounding factors.
7500 participants aged 40.28 ± 10.35 years were included in the study, of whom 2907 (38.76%) were women. Five LE8 trajectory patterns were identified. After around four-year follow-up, 667 hypertension events were observed. Compared to the Low-Stable trajectory, the hazard ratios and 95% confidence intervals for the Moderate-Increasing, Moderate-Decreasing, Moderate-Stable, and High-Stable trajectories were 0.51 (0.40, 0.65), 0.81 (0.64, 1.02), 0.45 (0.36, 0.58), 0.23 (0.16, 0.33), respectively. The risk of incident hypertension decreased as participants improved their LE8 status. The robustness of the primary results was confirmed through several sensitivity analyses.
LE8 trajectories were associated with the incident hypertension. People who improved their LE8 scores over time experienced a decreased risk of hypertension, even if they started with lower LE8 scores initially.
生命必需的 8 项指标（LE8）对慢性病的健康影响已被揭示，但它与高血压的关系尚不清楚。本研究旨在探讨 10 年 LE8 轨迹与高血压发病之间的潜在联系。
LE8 由四个行为和四个代谢因素组成，范围从 0 到 100。使用潜在混合模型来识别 2006 年至 2016 年期间 LE8 评分的轨迹。根据 2016 年至 2020 年的自我报告临床诊断和体检，诊断出高血压病例。采用 Cox 模型评估 LE8 轨迹与高血压的相关性。除了纳入 2006 年至 2016 年的平均 hs-CRP 水平外，还调整了年龄、性别、月收入、教育水平和招募时的职业等混杂因素。
研究纳入了 7500 名年龄为 40.28±10.35 岁的参与者，其中 2907 名（38.76%）为女性。确定了五种 LE8 轨迹模式。经过大约四年的随访，观察到 667 例高血压事件。与低稳定轨迹相比，中升高、中降低、中稳定和高稳定轨迹的风险比和 95%置信区间分别为 0.51（0.40，0.65）、0.81（0.64，1.02）、0.45（0.36，0.58）、0.23（0.16，0.33）。随着参与者 LE8 状况的改善，高血压的发病风险降低。通过几项敏感性分析证实了主要结果的稳健性。
LE8 轨迹与高血压的发病有关。随着时间的推移，LE8 评分提高的人患高血压的风险降低，即使他们最初的 LE8 评分较低。
