Nagpaul J P, Singh R, Amma M K, Majumdar S
Biochem Int. 1985 Feb;10(2):273-81.
The effects of steroidal oral contraceptive norethynodrel plus ethinylestradiol-3-methyl ether (SOC) at a daily dose of 5 mg: 0.06 mg per kg body weight for 28 days on intestinal absorptive functions have been investigated in protein-deficient female albino rats. The administration of this contraceptive caused significant increase in glucose and amino acids uptake but had no effect on calcium and zinc uptake in pair-fed as well as in protein-deficient rat. Further studies carried out on glucose transport system showed that the transport of sodium-dependent glucose was significantly enhanced while that of sodium-independent glucose remained unaltered in drug-treated animals. Kinetic studies of glucose transport in the presence of sodium ions revealed that SOC treatment affected the rate of uptake of glucose by elevating Vmax, but the apparent Kt value remained the same in treated and untreated animals.
已在蛋白质缺乏的雌性白化病大鼠中研究了每日剂量为5毫克（即每公斤体重0.06毫克）的甾体口服避孕药炔诺孕酮加炔雌醇-3-甲醚（SOC）连续28天对肠道吸收功能的影响。给予这种避孕药后，在配对喂养以及蛋白质缺乏的大鼠中，葡萄糖和氨基酸的摄取显著增加，但对钙和锌的摄取没有影响。对葡萄糖转运系统进行的进一步研究表明，在药物治疗的动物中，钠依赖性葡萄糖的转运显著增强，而钠非依赖性葡萄糖的转运保持不变。在存在钠离子的情况下对葡萄糖转运进行的动力学研究表明，SOC处理通过提高Vmax影响葡萄糖的摄取速率，但在处理和未处理的动物中，表观Kt值保持相同。
