开始使用肿瘤坏死因子-α抑制剂治疗炎症性肠病和类风湿关节炎的患者侵袭性真菌感染的发病率及危险因素
Incidence and Risk Factors for Invasive Fungal Infections in Patients Initiating Tumor Necrosis Factor-Alpha Inhibitors for Inflammatory Bowel Disease and Rheumatoid Arthritis.
作者信息
Hennessee Ian, Benedict Kaitlin, Bahr Nathan C, Lipner Shari R, Gold Jeremy A W
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Clin Infect Dis. 2025 Feb 24;80(2):364-366. doi: 10.1093/cid/ciae444.
In a commercial claims database analysis, <0.5% of patients with inflammatory bowel disease or rheumatoid arthritis developed an invasive fungal infection (IFI) within 1 year of initiating tumor necrosis factor-alpha therapy. Histoplasmosis was the most common IFI type. Overall IFI incidence varied based on region, underlying conditions, and use of certain immunosuppressive medications.
在一项商业索赔数据库分析中，炎症性肠病或类风湿性关节炎患者中，不到0.5%在开始肿瘤坏死因子-α治疗的1年内发生侵袭性真菌感染（IFI）。组织胞浆菌病是最常见的IFI类型。总体IFI发病率因地区、基础疾病和某些免疫抑制药物的使用情况而异。
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