Lin Hong-Min, Ren Sai-Yan, Cui Fei-Hu, Pan Ying-Ming, Tang Hai-Tao
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Chem Commun (Camb). 2024 Sep 16;60(75):10394-10397. doi: 10.1039/d4cc03570d.
Compounds comprising S-S bonds serve as significant pharmacological scaffolds in medicinal chemistry and natural products. We have devised an efficient electrochemical method for the construction of asymmetric disulfide bonds, leading to the synthesis of unsymmetric thiosulfonates. Compared with existing synthesis methods, our work not only avoids the use of metals and oxidants, but also realizes the operation of a one-pot three-component method, which makes this strategy extremely attractive.
包含S-S键的化合物在药物化学和天然产物中是重要的药理支架。我们设计了一种高效的电化学方法来构建不对称二硫键，从而合成不对称硫代磺酸酯。与现有的合成方法相比，我们的工作不仅避免了使用金属和氧化剂，还实现了一锅三组分法的操作，这使得该策略极具吸引力。
