橙皮苷和柚皮苷对阿尔茨海默病保护作用的基本研究方法
Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease.
作者信息
Kuşi Müjgan, Becer Eda, Vatansever Hafize Seda
机构信息
Faculty of Health Sciences, Department of Nutrition and Dietetics, Near East University, Nicosia, North Cyprus via Mersin 10, Turkey.
Research Center for Science, Technology and Engineering (BILTEM), Near East University, Nicosia, North Cyprus via Mersin 10, Turkey.
出版信息
Nutr Neurosci. 2025 May;28(5):550-562. doi: 10.1080/1028415X.2024.2397136. Epub 2024 Sep 3.
OBJECTIVES
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. This situation imposes a great burden on individuals, both economically and socially. Today, an effective method for treating the disease and protective approach to tau accumulation has not been developed yet. Studies have been conducted on the effects of hesperidin and naringin flavonoids found in citrus fruits on many diseases.
METHODS
In this review, the pathophysiology of AD is defined, and the effects of hesperidin and naringin on these factors are summarized.
RESULTS
Studies have shown that both components may potentially affect AD due to their antioxidative and anti-inflammatory properties. Based on these effects of the components, it has been shown that they may have ameliorative effects on Aβ, α-synuclein aggregation, tau pathology, and cognitive functions in the pathophysiology of AD.
DISCUSSION
There are studies suggesting that hesperidin and naringin may be effective in the prevention/treatment of AD. When these studies are examined, it is seen that more studies should be conducted on the subject.
目的
阿尔茨海默病（AD）是一种以认知障碍为特征的神经退行性疾病。这种情况给个人带来了巨大的经济和社会负担。目前，尚未开发出治疗该疾病的有效方法以及针对tau蛋白积累的保护措施。针对柑橘类水果中发现的橙皮苷和柚皮苷类黄酮对多种疾病的影响已开展了多项研究。
方法
在本综述中，对AD的病理生理学进行了定义，并总结了橙皮苷和柚皮苷对这些因素的影响。
结果
研究表明，这两种成分因其抗氧化和抗炎特性可能对AD产生潜在影响。基于这些成分的作用，已表明它们可能对AD病理生理学中的Aβ、α-突触核蛋白聚集、tau蛋白病变和认知功能具有改善作用。
讨论
有研究表明橙皮苷和柚皮苷可能对AD的预防/治疗有效。审视这些研究时发现，该主题还需要开展更多研究。
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