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经皮冠状动脉介入旋磨术期间心脏骤停的危险因素——基于大型国家登记处的分析

Risk factors of cardiac arrest during a percutaneous coronary intervention performed with rotational atherectomy - analysis based on a Large National Registry.

作者信息

Siłka Wojciech, Siudak Zbigniew, Malinowski Krzysztof P, Wańha Wojciech, Pawłowski Tomasz, Pietrasik Arkadiusz, Sielski Janusz, Kaziród-Wolski Karol, Kołtowski Łukasz, Wojakowski Wojciech, Legutko Jacek, Bartuś Stanisław, Januszek Rafał

机构信息

Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.

Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

出版信息

Cardiol J. 2024;31(6):785-793. doi: 10.5603/cj.97069. Epub 2024 Sep 3.

Abstract

BACKGROUND

Rotational atherectomy (RA) is traditionally administered for patients with heavily calcified lesions and is thereby characterized by a high risk of the performed intervention. However, the prevalence characteristics of cardiac arrest are poorly studied in this group of patients. We aimed to evaluate the frequency and risk factors of cardiac arrest during percutaneous coronary interventions (PCI) performed with RA and preceding coronary angiography (CA).

METHODS

Based on the data collected in the Polish Registry of Invasive Cardiology Procedures (ORPKI) from 2014 to 2021, we included 6522 patients who were treated with RA-assisted PCI. We scrutinized patient and procedural characteristics, as well as periprocedural complications, subsequently comparing groups in terms of cardiac arrest incidence with the use of univariable and multivariable analyses.

RESULTS

Thirty-five (0.5%) patients suffered from cardiac arrest during RA-PCI or preceding CA. They were characterized by significantly higher rates of prior stroke, acute coronary syndromes (ACS) as indications and higher Killip class (P < 0.001) at the admission time. Among the confirmed independent predictors of in-procedure cardiac arrest, the following can be noted: factors related to patients' clinical characteristics (e.g., older age, female sex, and disease burden), periprocedural characteristics (e.g., PCI within left main coronary artery [LMCA]), and periprocedural complications (e.g., coronary artery perforation and no-reflow phenomenon).

CONCLUSIONS

Severe clinical condition at baseline, expressed by ACS presence and Killip class IV, as well as RA-PCI performed within LMCA and other periprocedural complications, were the strongest predictors of cardiac arrest during RA-assisted PCI and CA.

摘要

背景

传统上,旋磨术(RA)用于治疗严重钙化病变的患者,因此该干预措施具有较高风险。然而,这组患者心脏骤停的流行特征研究较少。我们旨在评估在使用RA进行经皮冠状动脉介入治疗(PCI)及之前的冠状动脉造影(CA)过程中心脏骤停的发生率及危险因素。

方法

基于2014年至2021年波兰侵入性心脏病学程序注册中心(ORPKI)收集的数据,我们纳入了6522例行RA辅助PCI治疗的患者。我们仔细审查了患者和手术特征以及围手术期并发症,随后使用单变量和多变量分析比较了心脏骤停发生率的组间差异。

结果

35例(0.5%)患者在RA-PCI或之前的CA过程中发生心脏骤停。他们的特点是既往中风、急性冠状动脉综合征(ACS)作为适应证的发生率显著更高,且入院时Killip分级更高(P<0.001)。在已确认的术中心脏骤停独立预测因素中,可注意到以下因素:与患者临床特征相关的因素(如年龄较大、女性及疾病负担)、围手术期特征(如左主干冠状动脉[LMCA]内的PCI)以及围手术期并发症(如冠状动脉穿孔和无复流现象)。

结论

基线时严重的临床状况,以ACS的存在和Killip IV级表示,以及在LMCA内进行的RA-PCI和其他围手术期并发症,是RA辅助PCI和CA期间心脏骤停的最强预测因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf7d/11706255/3e007a6b8c2f/cardj-31-6-785f1.jpg

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