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本文引用的文献

1
Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt's voles (Lasiopodomys brandtii).肠道微生物群与光周期对雄性布氏田鼠（Lasiopodomys brandtii）季节性繁殖的影响有关。
Microbiome. 2022 Nov 15;10(1):194. doi: 10.1186/s40168-022-01381-1.
2
Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat.癸酸诺龙和十一酸睾酮对雄性大鼠的应激激素、神经递质系统及一般活动有不同影响。
Behav Brain Res. 2022 Aug 26;432:113971. doi: 10.1016/j.bbr.2022.113971. Epub 2022 Jun 20.
3
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.PD-1 抑制通过改变肠微生物群预防 TNBS 诱导的结肠炎。
Biomed Res Int. 2021 Jan 7;2021:4192451. doi: 10.1155/2021/4192451. eCollection 2021.
4
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice.亚精胺改善饮食诱导肥胖小鼠的肠道屏障完整性和肠道微生物群功能。
Gut Microbes. 2020 Nov 9;12(1):1-19. doi: 10.1080/19490976.2020.1832857.
5
Sodium Butyrate Alleviates Mouse Colitis by Regulating Gut Microbiota Dysbiosis.丁酸钠通过调节肠道微生物群失调缓解小鼠结肠炎。
Animals (Basel). 2020 Jul 7;10(7):1154. doi: 10.3390/ani10071154.
6
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes.高脂肪饮食引起的肠道微生物失调损害精子发生和精子活力。
Gut. 2020 Sep;69(9):1608-1619. doi: 10.1136/gutjnl-2019-319127. Epub 2020 Jan 2.
7
Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.NLRP3 炎性小体在糖尿病中的调节机制。
Biomolecules. 2019 Dec 9;9(12):850. doi: 10.3390/biom9120850.
8
Oxidative stress, inflammatory reactions and apoptosis mediated the negative effect of chronic stress induced by maternal separation on the reproductive system in male mice.氧化应激、炎症反应和细胞凋亡介导了母鼠分离引起的慢性应激对雄性小鼠生殖系统的负面影响。
Reprod Biol. 2019 Dec;19(4):340-348. doi: 10.1016/j.repbio.2019.10.003. Epub 2019 Nov 9.
9
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.二甲双胍通过缓解氧化应激诱导的血睾屏障损伤改善肥胖男性的生育能力。
Oxid Med Cell Longev. 2019 Sep 10;2019:9151067. doi: 10.1155/2019/9151067. eCollection 2019.
10
Longitudinal Survey of Fungi in the Human Gut: ITS Profiling, Phenotyping, and Colonization.人体肠道真菌的纵向调查：ITS 分析、表型分析与定殖
Front Microbiol. 2019 Jul 10;10:1575. doi: 10.3389/fmicb.2019.01575. eCollection 2019.

肠道微生物群通过抑制 NLRP3/ASC/caspase-1 轴改善肥胖小鼠的生殖功能障碍。

The gut microbiota improves reproductive dysfunction in obese mice by suppressing the NLRP3/ASC/caspase-1 axis.

机构信息

Chengdu Medical College, Chengdu, Sichuan, 610500, P. R. China.

Department of Gastroenterology, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, P. R. China.

出版信息

Future Microbiol. 2024;19(16):1389-1405. doi: 10.1080/17460913.2024.2386867. Epub 2024 Sep 3.

DOI:10.1080/17460913.2024.2386867
PMID:39225491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11552480/
Abstract

To explore the complex relationship between gut microbiota, obesity-related male reproductive impairments, and the NLRP3 inflammasome. A high-fat diet was administered to induce obesity in a mouse model, fecal microbiota transplantation or a high-dietary fiber diet (HDFD) was administered for 5 weeks to evaluate changes in parameters related to reproductive capacity, NLRP3, gut microbiota composition and metabolites in mice. A high-fat diet induces obesity and decreases reproductive capacity in male mice. Fecal microbiota transplantation and HDFD can improve reproductive capacity in obese mice by adjusting the gut microbiota population to suppress the NLRP3/ASC/caspase-1 axis, thereby reducing IL-1β levels. This study offers a potential treatment for obesity-induced reproductive dysfunction by targeting the gut microbiota and the NLRP3 inflammasome pathway.

摘要

探讨肠道微生物群、肥胖相关男性生殖损伤和 NLRP3 炎性小体之间的复杂关系。通过给予高脂肪饮食诱导小鼠肥胖模型，给予粪便微生物群移植或高膳食纤维饮食（HDFD）5 周，评估与生殖能力、NLRP3、肠道微生物群组成和代谢物相关的参数在肥胖小鼠中的变化。高脂肪饮食可诱导肥胖并降低雄性小鼠的生殖能力。粪便微生物群移植和 HDFD 可通过调整肠道微生物群种群来抑制 NLRP3/ASC/caspase-1 轴，从而降低 IL-1β 水平，改善肥胖小鼠的生殖能力。本研究通过靶向肠道微生物群和 NLRP3 炎性小体途径为肥胖引起的生殖功能障碍提供了一种潜在的治疗方法。