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The mechanistic insights behind the anticancer effects of statins in liver cancer.

作者信息

Chen Yiling, Wong Carmen Chak-Lui

机构信息

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China.

出版信息

Hepatol Commun. 2024 Sep 3;8(9). doi: 10.1097/HC9.0000000000000519. eCollection 2024 Sep 1.

DOI:10.1097/HC9.0000000000000519
PMID:39225688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371310/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e94/11371310/b5261a7f56bd/hc9-8-e0519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e94/11371310/b5261a7f56bd/hc9-8-e0519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e94/11371310/b5261a7f56bd/hc9-8-e0519-g001.jpg

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1
The mechanistic insights behind the anticancer effects of statins in liver cancer.他汀类药物在肝癌中抗癌作用背后的机制性见解。
Hepatol Commun. 2024 Sep 3;8(9). doi: 10.1097/HC9.0000000000000519. eCollection 2024 Sep 1.
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本文引用的文献

1
Association between statin use and the prognosis of hepatocellular carcinoma after resection: a nationwide cohort study.他汀类药物使用与肝细胞癌切除术后预后的关联：一项全国性队列研究。
EClinicalMedicine. 2023 Nov 1;65:102300. doi: 10.1016/j.eclinm.2023.102300. eCollection 2023 Nov.
2
Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.全球肝细胞癌流行病学趋势：对筛查、预防和治疗的启示。
Nat Rev Clin Oncol. 2023 Dec;20(12):864-884. doi: 10.1038/s41571-023-00825-3. Epub 2023 Oct 26.
3
Statin use and the risk of hepatocellular carcinoma among patients with chronic hepatitis B: an emulated target trial using longitudinal nationwide population cohort data.
他汀类药物的使用与慢性乙型肝炎患者肝细胞癌风险的关系：一项使用纵向全国人群队列数据模拟目标试验。
BMC Gastroenterol. 2023 Oct 25;23(1):366. doi: 10.1186/s12876-023-02996-w.
4
Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton.亲脂性他汀类药物通过 Rho 介导的肌动蛋白细胞骨架调节抑制 HCC 细胞中的 YAP 共激活剂转录活性。
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 1;325(3):G239-G250. doi: 10.1152/ajpgi.00089.2023. Epub 2023 Jun 27.
5
Effect of statins on the recurrence of hepatocellular carcinoma after liver transplantation: An illusion revealed by exposure density sampling.他汀类药物对肝移植后肝细胞癌复发的影响：暴露密度抽样揭示的假象。
Liver Int. 2023 Sep;43(9):2017-2025. doi: 10.1111/liv.15653. Epub 2023 Jun 27.
6
Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality.他汀类药物的使用与肝病、肝细胞癌和与肝脏相关的死亡率的关系。
JAMA Netw Open. 2023 Jun 1;6(6):e2320222. doi: 10.1001/jamanetworkopen.2023.20222.
7
A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.TAZ-TEAD2 通路通过 ANLN 和 KIF23 驱动肝细胞癌的生长，这是一个有治疗潜力的靶点。
Gastroenterology. 2023 Jun;164(7):1279-1292. doi: 10.1053/j.gastro.2023.02.043. Epub 2023 Mar 7.
8
Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.他汀类药物和阿司匹林对酒精性肝硬化相关 HCC 风险的影响：全国模拟试验。
Hepatol Commun. 2023 Jan 3;7(1):e0013. doi: 10.1097/HC9.0000000000000013. eCollection 2023 Jan 1.
9
Atorvastatin shows antitumor effect in hepatocellular carcinoma development by inhibiting angiogenesis via TGF-β1/pERK signaling pathway.阿托伐他汀通过TGF-β1/pERK信号通路抑制血管生成，在肝细胞癌发展过程中显示出抗肿瘤作用。
Mol Carcinog. 2023 Mar;62(3):398-407. doi: 10.1002/mc.23494. Epub 2022 Dec 28.
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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma.胆固醇抑制肝癌细胞中 GOLM1 依赖性 RTKs 的选择性自噬。
Cell Rep. 2022 Apr 19;39(3):110712. doi: 10.1016/j.celrep.2022.110712.