Türkoğlu İnci, Sacinti Koray Gorkem, Panattoni Andrea, Namazov Ahmet, Sanlier Nazlı Tunca, Sanlier Nevin, Cela Vito
Department of Nutrition and Dietetics, Hacettepe University School of Health Sciences, Ankara 06100, Turkey.
Department of Obstetrics and Gynecology, Aksaray University Training and Research Hospital, Aksaray 68200, Turkey.
Nutr Rev. 2025 May 1;83(5):869-879. doi: 10.1093/nutrit/nuae120.
Endometriosis is a chronic gynecological disorder affecting millions of women worldwide, causing chronic pelvic pain, dyspareunia, dysmenorrhea, and infertility, and severely impacting their quality of life. Treatment primarily involves hormonal therapies and surgical excision, but high recurrence rates and the economic burden are substantial. With these challenges, significant discussion surrounds the potential role of dietary patterns in managing endometriosis, making it necessary to bridge this critical gap. This review investigates the current scientific evidence on the dietary patterns (eg, Mediterranean, vegetarian, anti-inflammatory, low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols [low-FODMAP], and Western-style diets) associated with endometriosis and provides a concise, yet thorough, overview on the subject. In addition, antioxidants, microbiota, and artificial intelligence (AI) and their potential roles were also evaluated as future directions. An electronic-based search was performed in MEDLINE, Embase, Cochrane Library, CINAHL, ClinicalTrials.gov, Scopus, and Web of Science. The current data on the topic indicate that a diet based on the Mediterranean and anti-inflammatory diet pattern, rich in dietary fiber, omega-3 fatty acids, plant-based protein, and vitamins and minerals, has a positive influence on endometriosis, yielding a promising improvement in patient symptoms. Preclinical investigations and clinical trials indicate that dietary antioxidants and gut microbiota modulation present potential new approaches in managing endometriosis. Also, AI may offer a promising avenue to explore how dietary components interact with endometriosis. Ultimately, considering genetic and lifestyle factors, a healthy, balanced, personalized approach to diet may offer valuable insights on the role of diet as a means of symptom improvement, facilitating the utilization of nutrition for the management of endometriosis.
子宫内膜异位症是一种慢性妇科疾病，影响着全球数百万女性，会导致慢性盆腔疼痛、性交困难、痛经和不孕，并严重影响她们的生活质量。治疗主要包括激素疗法和手术切除，但复发率高且经济负担沉重。面对这些挑战，饮食模式在子宫内膜异位症管理中的潜在作用引发了大量讨论，因此填补这一关键空白很有必要。本综述调查了目前关于与子宫内膜异位症相关的饮食模式（如地中海饮食、素食、抗炎饮食、低可发酵寡糖、双糖、单糖和多元醇[低FODMAP饮食]以及西式饮食）的科学证据，并对该主题进行了简洁而全面的概述。此外，还评估了抗氧化剂、微生物群以及人工智能（AI）及其潜在作用作为未来的发展方向。我们在MEDLINE、Embase、Cochrane图书馆、CINAHL、ClinicalTrials.gov、Scopus和科学网进行了基于电子的检索。关于该主题的当前数据表明，以地中海饮食和抗炎饮食模式为基础的饮食，富含膳食纤维、ω-3脂肪酸、植物性蛋白质以及维生素和矿物质，对子宫内膜异位症有积极影响，有望改善患者症状。临床前研究和临床试验表明，饮食抗氧化剂和肠道微生物群调节是管理子宫内膜异位症的潜在新方法。此外，人工智能可能为探索饮食成分与子宫内膜异位症之间的相互作用提供一条有前景的途径。最终，考虑到遗传和生活方式因素，采用健康、均衡、个性化的饮食方法可能会为饮食作为改善症状手段的作用提供有价值的见解，促进利用营养来管理子宫内膜异位症。
