[结肠腺癌中17号染色体的重排]
[Rearrangement of the chromosome 17 in colonic adenocarcinoma].
作者信息
Muleris M, Salmon R, Zafrani B, Girodet J, Dutrillaux B
出版信息
C R Acad Sci III. 1985;300(8):315-8.
PMID:3922580
Abstract
Chromosome studies on five cases of large bowel adenocarcinoma show a systematic rearrangement of chromosome No. 17 after breakage in its juxtacentromeric region (band 17 q 11). A frequent involvement of chromosome No. 8 (juxtacentromeric break) and the loss of chromosome No. 18 are also noticed. A review of the literature strengthens the hypothesis of a preferential involvement of these chromosomes in large bowel cancer.
摘要
对5例大肠腺癌进行的染色体研究显示，17号染色体在其近着丝粒区域（17q11带）断裂后发生了系统性重排。还发现8号染色体频繁受累（近着丝粒断裂）以及18号染色体缺失。文献综述强化了这些染色体在大肠癌中优先受累的假说。
Zotero 插件