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在危地马拉综合儿科肾脏病中心建立自体血管通路项目。

Establishing an autogenous vascular access program in a Guatemalan comprehensive pediatric nephrology center.

机构信息

Division of Vascular Surgery, Department of Surgery, School of Community Medicine, University of Oklahoma, 1919 S. Wheeling Avenue, Suite 600, Tulsa, OK, 74104, USA.

Servicio de Nefrología, Hipertensión, Diálisis y Trasplante, Departamento de Pediatría, Hospital Roosevelt/FUNDANIER, Guatemala City, Guatemala.

出版信息

Pediatr Nephrol. 2025 Jan;40(1):189-201. doi: 10.1007/s00467-024-06488-1. Epub 2024 Sep 3.

Abstract

BACKGROUND

The Guatemalan Foundation for Children with Kidney Diseases collaborated with Bridge of Life, a not-for-profit charitable organization, to establish a vascular access program. We reviewed our experience with graded surgical responsibility and structured didactic training, creating arteriovenous fistulas (AVF) for Guatemalan children.

METHODS

Pediatric vascular access missions were completed from 2015 to 2023 and analyzed retrospectively. Follow-up was completed by the Guatemalan pediatric surgeons, nephrologists, and nursing staff. AVF patency and patient survival were evaluated by Kaplan-Meier life-table analysis with univariate and multivariable association between patient demographic variables by Cox proportional hazards models.

RESULTS

Among a total of 153 vascular access operations, there were 139 new patient procedures, forming the study group for this review. The mean age was 13.6 years, 42.6% were female, and the mean BMI was 17.3. Radial or ulnar artery-based direct AVFs were established in 100 patients (71.9%) and ten of the 25 transposition procedures. Brachial artery inflow was required in 29 direct AVFs (20.9%). Two patients underwent femoral vein transpositions. Access-related distal ischemia was not encountered. Seven of the AVF patients later required access banding for arm edema; all had previous dialysis catheters (mean = 9, range 4-12). Primary and cumulative patency rates were 84% and 86% at 12 months and 64% and 81% at 24 months, respectively. The median follow-up was 12 months. Overall patient survival was 84% and 67% at 12 and 24 months, respectively. There were no deaths related to AVF access.

CONCLUSIONS

Safe and functional AVFs were established in a teaching environment within a Guatemalan comprehensive pediatric nephrology center.

摘要

背景

危地马拉儿童肾脏病基金会与非营利慈善组织生命之桥合作,建立了一个血管通路项目。我们回顾了我们在分级手术责任和结构化教学培训方面的经验,为危地马拉儿童建立动静脉瘘(AVF)。

方法

2015 年至 2023 年完成了儿科血管通路任务,并进行了回顾性分析。随访由危地马拉儿科外科医生、肾病学家和护理人员完成。通过 Kaplan-Meier 生命表分析评估 AVF 通畅率和患者生存率,并通过 Cox 比例风险模型对患者人口统计学变量进行单变量和多变量关联分析。

结果

在总共 153 例血管通路手术中,有 139 例为新患者手术,形成了本次回顾的研究组。患者平均年龄为 13.6 岁,42.6%为女性,平均 BMI 为 17.3。100 例患者(71.9%)建立了桡动脉或尺动脉直接 AVF,25 例转位手术中有 10 例。29 例直接 AVF 需要肱动脉流入。未发生与通路相关的远端缺血。7 例 AVF 患者后来因手臂肿胀需要通路束带;所有患者均有先前的透析导管(平均 9 个,范围 4-12 个)。12 个月时,AVF 的一期和累积通畅率分别为 84%和 86%,24 个月时分别为 64%和 81%。中位随访时间为 12 个月。总的患者生存率分别为 84%和 67%,在 12 个月和 24 个月时。无与 AVF 通路相关的死亡。

结论

在危地马拉综合儿科肾病中心的教学环境中,安全且功能正常的 AVF 得以建立。

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