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改良 Dunn 手术后不稳定型骺板-干骺端连续性中断的儿童股骨头骨骺滑脱,其发生股骨头骨骺坏死和并发症的风险低。

Low Rate of AVN and Complications in Unstable SCFE With Epiphyseal-metaphyseal Discontinuity After Treatment With a Modified Dunn Procedure.

机构信息

Department of Pediatric Surgery, Inselspital, University of Bern, Bern, Switzerland.

Department of Radiology, Inselspital, University of Bern, Bern, Switzerland.

出版信息

Clin Orthop Relat Res. 2024 Sep 1;482(9):1598-1610. doi: 10.1097/CORR.0000000000003123. Epub 2024 May 14.

Abstract

BACKGROUND

The risk of developing avascular necrosis (AVN) in the setting of an unstable slipped capital femoral epiphysis (SCFE) that is undergoing treatment with the modified Dunn procedure is not well understood. In addition, since the Loder classification of unstable is reportedly different than actual intraoperatively observed instability (that is, discontinuity between the femoral head epiphysis and proximal femoral metaphysis), the overall risk of developing AVN, as well as the potential complications of treatment of these patients with the modified Dunn procedure, are unknown.

QUESTIONS/PURPOSES: To evaluate the modified Dunn procedure for the treatment of patients with epiphyseal-metaphyseal discontinuity, we asked: (1) What was the survivorship free from AVN at 10 years? (2) What was the survivorship free from subsequent surgery and/or complications at 10 years? (3) What were the clinical and patient-reported outcome scores?

METHODS

In a retrospective analysis, we identified 159 patients (159 hips) treated with a modified Dunn procedure for SCFE between 1998 and 2020, of whom 97% (155 of 159) had documentation about intraoperatively observed epiphyseal-metaphyseal stability. Of those, 37% (58 of 155) of patients were documented to have intraoperatively observed epiphyseal-metaphyseal discontinuity and were considered eligible for inclusion, whereas 63% (97 of 155) had documented epiphyseal-metaphyseal stability and were excluded. No patients were lost to follow-up before the 2-year minimum. All patients were assessed for survival, but 7% (4 of 58) did not fill out our outcomes score questionnaire. This resulted in 93% (54 of 58) of patients who were available for outcome score assessment. Additionally, 50% (29 of 58) of patients had not been seen within the last 5 years; they are included, but we note that there is uncertainty about their status. The median (range) age at surgery was 13 years (10 to 16), and the sex ratio was 60% (35 of 58) male and 40% (23 of 58) female patients. Sixty-four percent (37 of 58) of patients were classified as acute-on-chronic, and 17% (10 of 58) of patients were classified as acute. Forty-seven percent (27 of 58) of patients presented with severe slips and 43% (25 of 58) of patients with moderate slips based on radiographic classification. All patients underwent surgical hip dislocation with the modified Dunn procedure to correct the slip deformity and provide stabilization. Complications and reoperations were assessed from a review of electronic medical records, and a Kaplan-Meier estimator was used to estimate survivorship free from complications and reoperations at 10 years. Clinical examination results and questionnaire responses were evaluated at minimum 2-year follow-up.

RESULTS

Kaplan-Meier survivorship free from AVN was 93% (95% CI 87% to 100%) at 10 years. Survivorship free from any reoperation was 75% (95% CI 64% to 88%) at 10 years. In addition, survivorship free from complications, defined as development of AVN, reoperation, or a Sink Grade II complication or higher, was 57% (95% CI 45% to 73%) at 10 years. The median (range) Merle D'Aubigne Postel score was 18 (14 to 18) for the patients who did not develop AVN, and 12 (6 to 16) for the four patients who developed AVN (p < 0.001). The median modified Harris hip score was 100 (74 to 100) in the non-AVN cohort and 65 (37 to 82) in the AVN cohort (p = 0.001). Median HOOS total score was 95 (50 to 100) in the non-AVN cohort and 53 (40 to 82) in the AVN cohort (p = 0.002).

CONCLUSION

Although the modified Dunn procedure is technically challenging, this study shows that in experienced hands, patients with who have demonstrated epiphyseal-metaphyseal discontinuity can be treated with a low risk of AVN and subsequent surgery. Referral of these patients to specialists who have substantial expertise in this procedure is recommended to improve patient outcomes. Prospective, long-term observational studies will help us identify these high-risk patients preoperatively and determine the long-term success of this procedure.

LEVEL OF EVIDENCE

Level IV, therapeutic study.

摘要

背景

在不稳定型股骨颈骨骺滑脱(SCFE)接受改良邓恩手术治疗的情况下,发生缺血性坏死(AVN)的风险尚不清楚。此外,由于不稳定的 Loder 分类据称与术中观察到的实际不稳定性不同(即股骨头骨骺与股骨近端干骺端之间的连续性中断),因此,发生 AVN 的总体风险以及这些患者接受改良邓恩手术治疗的潜在并发症尚不清楚。

问题/目的:为了评估改良邓恩手术治疗骨骺干骺端连续性中断的患者,我们提出了以下问题:(1)10 年时无 AVN 生存率是多少?(2)10 年时无后续手术和/或并发症生存率是多少?(3)临床和患者报告的结果评分是多少?

方法

在回顾性分析中,我们确定了 1998 年至 2020 年间接受改良邓恩手术治疗的 159 例(159 髋)SCFE 患者,其中 97%(155/159)有术中观察到的骨骺干骺端稳定性的相关记录。在这些患者中,37%(58/155)的患者被记录为术中观察到骨骺干骺端连续性中断,符合纳入标准,而 63%(97/155)的患者有记录的骨骺干骺端稳定性,被排除在外。所有患者在 2 年的最低随访时间前均未失访。所有患者均进行了生存评估,但 7%(4/58)未填写我们的结局评分问卷。这导致 93%(54/58)的患者可进行结局评分评估。此外,50%(29/58)的患者在过去 5 年内未就诊;他们包括在内,但我们注意到他们的情况存在不确定性。手术时的中位(范围)年龄为 13 岁(10-16 岁),性别比例为 60%(35/58)为男性,40%(23/58)为女性。64%(37/58)的患者为慢性急性发作,17%(10/58)的患者为急性发作。47%(27/58)的患者为严重滑脱,43%(25/58)的患者为中度滑脱,基于影像学分类。所有患者均接受改良邓恩手术行髋关节脱位以矫正滑脱畸形并提供稳定。并发症和再次手术的评估是通过查阅电子病历进行的,Kaplan-Meier 估计法用于估计 10 年时无并发症和再次手术的生存率。临床检查结果和问卷回答在至少 2 年的随访时进行评估。

结果

Kaplan-Meier 无 AVN 生存率为 93%(95%CI 87%-100%),10 年时无任何再手术生存率为 75%(95%CI 64%-88%)。此外,定义为发生 AVN、再次手术或 Sink 分级 II 级及以上并发症的无并发症生存率为 57%(95%CI 45%-73%),10 年时无并发症生存率。未发生 AVN 的患者中,Merle D'Aubigne Postel 评分的中位数(范围)为 18(14-18),发生 AVN 的 4 名患者的评分分别为 12(6-16)(p<0.001)。非 AVN 组的改良 Harris 髋关节评分中位数为 100(74-100),AVN 组为 65(37-82)(p=0.001)。非 AVN 组的 HOOS 总分中位数为 95(50-100),AVN 组为 53(40-82)(p=0.002)。

结论

尽管改良邓恩手术技术具有挑战性,但本研究表明,在经验丰富的医生手中,对于已经显示骨骺干骺端连续性中断的患者,可以采用这种手术,发生 AVN 和后续手术的风险较低。建议将这些患者转介给在该手术方面具有丰富专业知识的专家,以改善患者的预后。前瞻性、长期观察性研究将帮助我们在术前识别这些高危患者,并确定该手术的长期效果。

证据水平

IV 级,治疗性研究。

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