Ghosal Doyel, Majumder Nilotpal, Das Pratik, Chaudhary Shivani, Dey Sovan, Banerjee Priya, Tiwari Preeti, Das Piyali, Basak Piyali, Nandi Samit K, Ghosh Sourabh, Kumar Sachin
Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
Adv Healthc Mater. 2024 Dec;13(32):e2402024. doi: 10.1002/adhm.202402024. Epub 2024 Sep 3.
In the pursuit of new wound care products, researchers are exploring methods to improve wound healing through exogenous wound healing products. However, diverging from this conventional approach, this work has developed an endogenous support system for wound healing, drawing inspiration from the body's innate healing mechanisms governed by the sequential release of metal ions by body at wound site to promote different stages of wound healing. This work engineers a multi-ion-releasing sprayable hydrogel system, to mimic this intricate process, representing the next evolutionary step in wound care products. It comprises Alginate (Alg) and Fibrin (Fib) hydrogel infused with Polylactic acid (PLA) polymeric microcarriers encapsulating multi (calcium, copper, and zinc) nanoparticles (Alg-Fib-PLA-nCMB). Developed sprayable Alg-Fib-PLA-nCMB hydrogel show sustained release of beneficial multi metallic ions at wound site, offering a range of advantages including enhanced cellular function, antibacterial properties, and promotion of crucial wound healing processes like cell migration, ROS mitigation, macrophage polarization, collagen deposition, and vascular regeneration. In a comparative study with a commercial product (Midstress spray), developed Alg-Fib-PLA-nCMB hydrogel demonstrates superior wound healing outcomes in a rat model, indicating its potential for next generation wound care product, addressing critical challenges and offering a promising avenue for future advancements in the wound management.
在寻求新型伤口护理产品的过程中，研究人员正在探索通过外源性伤口愈合产品来改善伤口愈合的方法。然而，与这种传统方法不同的是，这项工作开发了一种用于伤口愈合的内源性支持系统，其灵感来源于身体在伤口部位通过金属离子的顺序释放来控制的固有愈合机制，以促进伤口愈合的不同阶段。这项工作设计了一种多离子释放的可喷涂水凝胶系统，以模拟这一复杂过程，代表了伤口护理产品的下一个进化阶段。它由海藻酸盐（Alg）和纤维蛋白（Fib）水凝胶组成，其中注入了包裹多（钙、铜和锌）纳米颗粒的聚乳酸（PLA）聚合物微载体（Alg-Fib-PLA-nCMB）。所开发的可喷涂Alg-Fib-PLA-nCMB水凝胶在伤口部位显示出有益多金属离子的持续释放，具有一系列优势，包括增强细胞功能、抗菌特性以及促进关键的伤口愈合过程，如细胞迁移、活性氧减轻、巨噬细胞极化、胶原蛋白沉积和血管再生。在与一种商业产品（Midstress喷雾）的对比研究中，所开发的Alg-Fib-PLA-nCMB水凝胶在大鼠模型中显示出优异的伤口愈合效果，表明其作为下一代伤口护理产品的潜力，解决了关键挑战，并为伤口管理的未来进展提供了一条有前景的途径。
