Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China.
Department of Nursing, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China.
Photodiagnosis Photodyn Ther. 2024 Oct;49:104304. doi: 10.1016/j.pdpdt.2024.104304. Epub 2024 Sep 2.
Acne vulgaris is a chronic inflammatory skin disease involving the pilosebaceous unit.
To assess the efficacy and safety of a chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) in the treatment of mild to moderate acne patients.
In this prospective patient single-blind randomized split-face controlled study, patients diagnosed with mild to moderate acne were treated with four sessions of STBF-PDT on one-half of the face, while the other half were treated with the same dose of red-light treatment without photosensitizer. Follow-up assessment including the skin lesion clearance rate, facial fluorescence scattering spots on VISIA Porphyrins mode, and skin physiological parameters was conducted before and after treatment as well as 2 and 4 weeks after the final treatment.
A total of 26 patients were recruited, of which 22 patients completed this study. STBF-PDT is significantly effective in improving lesions in patients with acne. The clearance rate of total lesions was 67.42±8.51 % in the STBF-PDT group and 41.05±11.97 % in the control group 4 weeks after the treatment (P < 0.001). The average clearance rate of inflammatory lesions was 84.41±7.13 % in the STBF-PDT group and 50.10±13.91 % in the control group, with a statistically significance (P < 0.0001). The skin sebum of the STBF-PDT side was significantly lower than that on the control side. There was no obvious adverse reaction especially no pain or reactive acne.
STBF-PDT may be a safe and effective treatment for mild to moderate acne and can significantly inhibit sebum secretion.
寻常痤疮是一种累及毛囊皮脂腺单位的慢性炎症性皮肤病。
评估氯化 e6 衍生物介导的光动力疗法（STBF-PDT）治疗轻中度痤疮患者的疗效和安全性。
在这项前瞻性患者单盲随机对照分面研究中，诊断为轻中度痤疮的患者接受了四次 STBF-PDT 治疗，其中一半面部接受治疗，另一半面部接受相同剂量的无光敏剂红光治疗。治疗前后以及最后一次治疗后 2 周和 4 周，进行皮肤病变清除率、VISIA 卟啉模式下面部荧光散射点以及皮肤生理参数的随访评估。
共招募了 26 名患者，其中 22 名患者完成了这项研究。STBF-PDT 对改善痤疮患者的病变非常有效。治疗 4 周后，STBF-PDT 组总病变清除率为 67.42±8.51%，对照组为 41.05±11.97%（P<0.001）。STBF-PDT 组炎症性病变的平均清除率为 84.41±7.13%，对照组为 50.10±13.91%，差异具有统计学意义（P<0.0001）。STBF-PDT 侧皮肤皮脂明显低于对照组。无明显不良反应，尤其无疼痛或反应性痤疮。
STBF-PDT 可能是治疗轻中度痤疮的一种安全有效的方法，可以显著抑制皮脂分泌。
