Hayashi Jun, Nakai Shingo, Kobayashi Kimihiro, Kuroda Yoshinori, Ohba Eiichi, Mizumoto Masahiro, Yamashita Atsushi, Ochiai Tomonori, Uchida Tetsuro
Second Department of Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Gen Thorac Cardiovasc Surg. 2025 Apr;73(4):218-226. doi: 10.1007/s11748-024-02074-2. Epub 2024 Sep 4.
During total arch replacement (TAR) using frozen elephant trunk (FET) technique with Frozenix for true thoracic aortic aneurysm (tTAA), oversized FET tends to be chosen similar to the endovascular devise selection. However, the oversized FET is considered a risk factor for intimal injury. The appropriate size selection of FET remains insufficiently understood.
Between October 2014 and March 2022, a total of 49 patients underwent TAR using Frozenix for tTAA. Out of 49 patients, four patients planned to staged surgery were excluded, 19 patients were operated on with an undersized Frozenix compared with the descending aorta (undersized FET group) and in 26 patients an equal or oversized Frozenix was used (oversized FET group). Clinical outcomes and postoperative diameter changes were investigated.
In-hospital mortality was 0%. The mean diameter of Frozenix and the descending aorta was 30.7 mm and 28.8 mm, respectively, in the oversized FET group, and 26.7 mm and 30.1 mm in the undersized FET group. Postoperative computed tomography (CT) demonstrated no endoleaks not only in the oversized FET group but also in the undersized FET group. CT also revealed that undersized FET had expanded more than the original diameter in all cases except for two, with an average of 2.47 ± 1.53 mm. Additionally, the descending aorta covered with Frozenix shrank in 10 patients (53%). Postoperative adverse aortic events were not observed.
Undersized Frozenix tightly fit the descending aorta and resulted in complete sealing without endoleaks. Oversized FET is not strictly necessary considering the size-related adverse complications.
在使用Frozenix冷冻象鼻(FET)技术治疗真性胸主动脉瘤(tTAA)进行全弓置换(TAR)时,与血管内装置的选择类似,往往会选择尺寸过大的FET。然而,尺寸过大的FET被认为是内膜损伤的一个危险因素。FET的合适尺寸选择仍未得到充分了解。
2014年10月至2022年3月期间,共有49例患者使用Frozenix进行tTAA的TAR。在这49例患者中,排除4例计划分期手术的患者,19例患者使用的Frozenix尺寸小于降主动脉(尺寸过小的FET组),26例患者使用的Frozenix尺寸相等或过大(尺寸过大的FET组)。研究临床结果和术后直径变化。
住院死亡率为0%。尺寸过大的FET组中,Frozenix和降主动脉的平均直径分别为30.7 mm和28.8 mm,尺寸过小的FET组中分别为26.7 mm和30.1 mm。术后计算机断层扫描(CT)显示,尺寸过大的FET组和尺寸过小的FET组均未出现内漏。CT还显示,除2例患者外,尺寸过小的FET在所有病例中均比原始直径扩张得更多,平均扩张2.47±1.53 mm。此外,10例患者(53%)中覆盖Frozenix的降主动脉出现了收缩。未观察到术后主动脉不良事件。
尺寸过小的Frozenix与降主动脉紧密贴合,实现了完全密封且无内漏。考虑到与尺寸相关的不良并发症,尺寸过大的FET并非严格必需。