Department of Community Medicine, Faculty of Medicine, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Sci Rep. 2024 Sep 3;14(1):20500. doi: 10.1038/s41598-024-69975-3.
Hodgkin lymphoma (HL) is a rare malignancy affecting the lymphatic system. Our study examined the incidence rates of adult HL based on sex, race/ethnicity, age, and histological subgroups in the United States (US) from 2000 to 2020. Data for this study were extracted from the Surveillance, Epidemiology, and End Results 22 database. HL patients were identified utilizing the International Classification of Diseases for Oncology version 3 and categorized as classical HL, lymphocyte-rich/mixed cell/lymphocyte depleted, nodular sclerosis, classical HL, not otherwise specified, and nodular lymphocyte-predominant HL. The study reported average annual percent change (AAPC). All estimates were presented as counts and age-standardized incidence rates (ASIRs) per 100,000 individuals. Between 2000 and 2019, a total of 70,924 cases of HL were reported in the US. Classical HL was the predominant subtype (94.27%), and most incident cases were among non-Hispanic Whites (66.92%) and those aged 20-29 years (24.86%). The ASIR per 100,000 population was 3.83 for men and 2.92 for women. Both sexes showed declines in the AAPCs between 2000 and 2019 (- 0.64% [- 0.99, - 0.28] and - 0.40% [- 0.77, - 0.03] for men and women, respectively). There was a significant decrease in ASIRs after COVID-19 among both sexes (percent change: - 7.49% [- 11.58, - 3.40]). Throughout all age groups, men had a higher incidence rate compared to women, except for those aged 20-29 years. Although the overall HL incidence rate was lowered in the study period from 2000 to 2019, a dramatic decrease in ASIRs of HL patients following COVID-19 pandemic was observed.
霍奇金淋巴瘤（HL）是一种罕见的影响淋巴系统的恶性肿瘤。本研究基于美国（US） 2000 年至 2020 年的性别、种族/族裔、年龄和组织学亚组，检查了成人 HL 的发病率。本研究的数据来自监测、流行病学和最终结果 22 数据库。HL 患者利用国际肿瘤学疾病分类第 3 版进行识别，并分为经典 HL、富含淋巴细胞/混合细胞/淋巴细胞耗竭、结节硬化、经典 HL、非特指和结节性淋巴细胞优势 HL。研究报告了平均年变化百分比（AAPC）。所有估计值均以每 10 万人的计数和年龄标准化发病率（ASIR）表示。2000 年至 2019 年，美国共报告了 70924 例 HL。经典 HL 是主要亚型（94.27%），大多数发病病例发生在非西班牙裔白人（66.92%）和 20-29 岁年龄组（24.86%）。每 10 万人的 ASIR 为男性 3.83，女性 2.92。男女两性 2000 年至 2019 年的 AAPC 均呈下降趋势（男性为-0.64%[-0.99，-0.28]和女性为-0.40%[-0.77，-0.03]）。COVID-19 后，两性的 ASIR 均显著下降（变化百分比：-7.49%[-11.58，-3.40]）。在所有年龄组中，男性的发病率均高于女性，但 20-29 岁年龄组除外。尽管 2000 年至 2019 年期间 HL 的总体发病率有所下降，但 COVID-19 大流行后 HL 患者的 ASIR 急剧下降。
