用人尿促卵泡激素（美诺定）诱导松鼠猴（松鼠猴属）卵泡生长。
Induction of follicular growth in the squirrel monkey (Saimiri sciureus) with human urinary follicle-stimulating hormone (Metrodin).
作者信息
Yano J, Gould K G
出版信息
Fertil Steril. 1985 May;43(5):799-803. doi: 10.1016/s0015-0282(16)48569-9.
Human urinary follicle-stimulating hormone (Metrodin, Serono Laboratories, Inc., Randolph, MA), an investigational drug which is purified from human menopausal gonadotropin (hMG) (Pergonal, Serono Laboratories, Inc.), was tested for its effects on induction of follicle development in the squirrel monkey (Saimiri sciureus). Metrodin was as effective as hMG for induction of follicle development in the squirrel monkey, and it appeared to be superior to hMG or porcine follicle-stimulating hormone at lower dose rates. The percentage of cornified cells in vaginal smears increased during stimulation and showed a parallelism with estrogen levels in serum and with follicular development. The results of the recovery rate of matured ova in different regimens show that use of Metrodin is a most convenient method for induction of follicle development and ovum recovery in the squirrel monkey.
人尿促卵泡激素（美诺孕，雪兰诺实验室公司，马萨诸塞州伦道夫）是一种从人绝经期促性腺激素（hMG）（普丽康，雪兰诺实验室公司）中纯化得到的研究性药物，对其在松鼠猴（松鼠猴属）中诱导卵泡发育的作用进行了测试。美诺孕在诱导松鼠猴卵泡发育方面与hMG效果相当，且在较低剂量率下似乎优于hMG或猪促卵泡激素。阴道涂片角质化细胞百分比在刺激过程中增加，与血清雌激素水平及卵泡发育呈平行关系。不同方案中成熟卵子回收率的结果表明，使用美诺孕是诱导松鼠猴卵泡发育和卵子回收的最便捷方法。
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