Sokolova N A, Kopylova G N, Samonina G E, Kaverin M A
Fiziol Zh SSSR Im I M Sechenova. 1985 Apr;71(4):516-22.
In the frog heart isolated sinus node with intact extracardiac sympathetic and parasympathetic pathways or intracardiac nerves, the intracellular pacemaker APs and extracellular nervous activity of the parasympathetic postganglionic intracardiac pathways were recorded. Two major sympathetic-parasympathetic interaction patterns were revealed: the antagonistic and the augmentative ones. In initial deep bradycardia, sympathetic stimulation diminished the parasympathetic inhibition, whereas in initial parasympathetic tachycardia, sympathetic stimulation augmented these parasympathetic effects. The recording of the intracellular pacemaker AP showed the effect of a complicated interaction between the sympathetic and parasympathetic transmitters on the heart pacemaker. Parasympathetic postganglionic nervous activity changed in two ways: there was either an attenuation during intense sympathetic stimulation or an augmentation during a weak sympathetic stimulation. Relative significance of the sympathetic and parasympathetic systems in the heart rate control and possible mechanisms of the two patterns of sympathetic-parasympathetic interactions, are discussed.
在具有完整心外交感和副交感神经通路或心内神经的离体蛙心窦房结中，记录了细胞内起搏动作电位以及副交感神经节后心内通路的细胞外神经活动。揭示了两种主要的交感 - 副交感相互作用模式：拮抗模式和增强模式。在初始深度心动过缓时，交感神经刺激减弱了副交感神经抑制，而在初始副交感神经心动过速时，交感神经刺激增强了这些副交感神经效应。细胞内起搏动作电位的记录显示了交感和副交感递质对心脏起搏器的复杂相互作用的影响。副交感神经节后神经活动以两种方式变化：在强烈交感神经刺激期间要么减弱，要么在微弱交感神经刺激期间增强。讨论了交感和副交感神经系统在心率控制中的相对重要性以及两种交感 - 副交感相互作用模式的可能机制。
