Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.
School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Diabetes Obes Metab. 2024 Nov;26(11):5325-5335. doi: 10.1111/dom.15890. Epub 2024 Sep 4.
To study the association between femoral neck (FN) bone mineral density (BMD) T-score and fracture risk in individuals with and without type 2 diabetes (T2D).
We performed a single-centre retrospective cohort study using the Danish National Health Service. BMD of the FN was measured by dual-energy X-ray absorptiometry. Cox proportional hazards regression models were used to study the association between FN BMD T-score and fractures in individuals with and without T2D separately, adjusted for age, comorbidities and comedication. The results from this analysis were used to estimate the 10-year absolute fracture risk.
In total, there were 35,129 women (2362 with T2D) and 7069 men (758 with T2D). The FN BMD T-score was significantly associated with risk of any, hip and major osteoporotic fracture in men and women with [adjusted hazard risk ratios (aHR) women, hip: 1.57; 95% confidence interval (CI) 1.24-2.00, incidence rate (IR) 8.7; aHR men, hip: 1.55; 95% CI 1.01-2.36, IR 4.6] and without T2D (aHR women, hip: 1.75; 95% CI 1.64-1.87, IR 7.0; aHR men, hip: 1.97, 95% CI 1.73-2.25, IR 6.3), and its ability to predict fracture risk was similar. Fracture IRs were not significantly different for individuals with or without T2D, nor was the estimated cumulative 10-year fracture risk.
The FN BMD T-score was significantly associated with hip, non-spine and major osteoporotic fracture risk in men and women with and without T2D. Fracture risk for a given T-score and age was equal in individuals with and without T2D, as was the ability of the FN BMD T-score to predict fracture risk.
研究 2 型糖尿病（T2D）患者和非 T2D 患者的股骨颈（FN）骨密度（BMD）T 评分与骨折风险之间的关系。
我们使用丹麦国家卫生服务进行了一项单中心回顾性队列研究。FN 的 BMD 通过双能 X 射线吸收法测量。使用 Cox 比例风险回归模型分别研究了 T2D 患者和非 T2D 患者 FN BMD T 评分与骨折之间的关系，并调整了年龄、合并症和合并用药。该分析的结果用于估计 10 年绝对骨折风险。
共有 35129 名女性（2362 名患有 T2D）和 7069 名男性（758 名患有 T2D）。FN BMD T 评分与男性和女性的任何部位、髋部和主要骨质疏松性骨折风险显著相关[调整后的危险比（HR）女性，髋部：1.57；95%置信区间（CI）1.24-2.00，发病率（IR）8.7；HR 男性，髋部：1.55；95%CI 1.01-2.36，IR 4.6]和无 T2D（HR 女性，髋部：1.75；95%CI 1.64-1.87，IR 7.0；HR 男性，髋部：1.97，95%CI 1.73-2.25，IR 6.3），其预测骨折风险的能力相似。有或没有 T2D 的个体的骨折 IR 没有显著差异，估计的 10 年累积骨折风险也没有差异。
FN BMD T 评分与 T2D 患者和非 T2D 患者的髋部、非脊柱和主要骨质疏松性骨折风险显著相关。对于给定的 T 评分和年龄，T2D 患者和非 T2D 患者的骨折风险相等，FN BMD T 评分预测骨折风险的能力也相等。
