Aliyari Hamed, Sahraei Hedayat, Menhaj Mohammad Bagher, Kazemi Masoomeh, Vahidi Behrooz, Hosseinian Seyed Hossein
Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, United States.
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Basic Clin Neurosci. 2024 Mar-Apr;15(2):185-198. doi: 10.32598/bcn.2021.1340.5. Epub 2024 Mar 1.
Today, high-voltage (HV) lines create a pernicious environment for humans living or working in the vicinity and even under these lines. The male rhesus monkey is used to investigate the effects of fields produced by HV towers. This study examines the function and level of impact in rhesus monkeys' brains from the cerebellum's cognitive, biological, and structural perspective.
Two monkeys have been used, one as a control and the second as a test. The monkey under test was subjected to a simulated HV electrical field of 3 kV/m, 4 hours a day, for 1 month. Behavioral tests were performed using a device designed and built for this purpose. Concentration analysis of adrenocorticotropic hormones (ACTH) and inspection of glucocorticoid receptor gene's (GR) expression were performed by the reverse transcription polymerase chain reaction method. Changes in cerebellar anatomy were examined with magnetic resonance imaging (MRI). All tests were performed before and after the study period and compared with the control monkey.
Cognitive tests showed a significant reduction for the monkey exposed to the HV electrical field in the first week after imposition compared with the same time before. Also, the expression of the gene decreased, and the concentration of ACTH hormone in plasma increased. Surveying the level of cerebral MRI images did not show any difference, but hemorrhage was evident in a part of the cerebellum.
The tested monkey's cognitive, biological, and MRI results showed a decrease in visual learning and memory indices.
如今，高压（HV）线路对生活或工作在其附近甚至下方的人类造成了有害环境。雄性恒河猴被用于研究高压塔产生的电场的影响。本研究从恒河猴小脑的认知、生物学和结构角度，考察其大脑的功能及受影响程度。
使用了两只猴子，一只作为对照，另一只作为测试对象。测试猴子每天接受4小时、强度为3 kV/m的模拟高压电场，持续1个月。使用为此设计和制造的设备进行行为测试。通过逆转录聚合酶链反应法进行促肾上腺皮质激素（ACTH）的浓度分析和糖皮质激素受体基因（GR）表达的检测。用磁共振成像（MRI）检查小脑解剖结构的变化。所有测试均在研究期前后进行，并与对照猴子进行比较。
认知测试显示，与施加电场前同一时间相比，暴露于高压电场的猴子在施加后的第一周有显著下降。此外，该基因的表达下降，血浆中ACTH激素浓度升高。对脑部MRI图像水平的检查未显示任何差异，但小脑的一部分有明显出血。
受试猴子的认知、生物学和MRI结果显示视觉学习和记忆指标下降。
