钙逆转：在无钙培养基中，钙离子对大鼠子宫平滑肌中各种激动剂诱导的持续收缩的抑制作用。

Calcium reversal: inhibition by Ca ion of sustained contraction in Ca-free medium induced by various agonists in rat uterine smooth muscle.

作者信息

Sakai K, Higuchi-Nakamura K, Uchida M K

出版信息

Gen Pharmacol. 1985;16(2):133-6. doi: 10.1016/0306-3623(85)90050-3.

Abstract

Various agonists induced sustained contractions of estrogen-dominated rat uterine smooth muscle in Ca-free salt solution containing 0.2 mM EGTA after incubation of the muscle with 3 mM EGTA for 1 hr. The magnitudes of contraction varied with agonists. (bradykinin greater than oxytocin greater than or equal to vasopressin greater than PGF2 alpha greater than angiotensin II greater than acetylcholine greater than or equal to PGE2 greater than or equal to 5-hydroxytryptamine. Addition of 10(-4) Ca ion reduced the tension developed: Ca ion inhibited these contractions when they were sufficiently large (marked inhibition on bradykinin-, oxytocin-, and vasopressin-induced contractions; definite one on PGF2 alpha-induced contraction), as observed previously with oxytocin-induced contraction under the same conditions and named "Ca Reversal".

摘要

在将大鼠子宫平滑肌与3 mM乙二醇双四乙酸（EGTA）孵育1小时后，在含有0.2 mM EGTA的无钙盐溶液中，各种激动剂诱导了雌激素主导的大鼠子宫平滑肌的持续收缩。收缩幅度因激动剂而异。（缓激肽＞催产素≥血管加压素＞前列腺素F2α＞血管紧张素II＞乙酰胆碱≥前列腺素E2≥5-羟色胺）。添加10⁻⁴钙离子可降低所产生的张力：当这些收缩足够大时，钙离子会抑制它们（对缓激肽、催产素和血管加压素诱导的收缩有明显抑制作用；对前列腺素F2α诱导的收缩有确切抑制作用），这与之前在相同条件下观察到的催产素诱导的收缩情况相同，被称为“钙逆转”。