Takayama T
Nihon Heikatsukin Gakkai Zasshi. 1986 Feb;22(1):31-42. doi: 10.1540/jsmr1965.22.31.
The effects of prostaglandins were studied on the contractile activities in isolated myometrial or vaginal strips from humans and rats by recording isometric tension development. PGE2 decreased the contractility in corpus and cervix from non pregnant human uterus, but increased the contractility in corpus and decreased the contractility in cervix from term human uterus. PGF2 alpha increased the contractility in corpus and cervix from non pregnant and term human uterus. PGE2 increased the contractility in corpus, but decreased the contractility in cervix and vagina from non pregnant and term rats. PGF2 alpha increased the contractilities in corpus, cervix and vagina from non pregnant and term rats. The effects of prostaglandins were studied on an intracellular Ca store in the depolarized uterine smooth muscle cells from non pregnant rats. The activative effects on the contractile mechanism by prostaglandins supported the suggestion that prostaglandins have an activative action on Ca2+ influx and Ca2+ release from intracellular Ca store. The inhibitory effects on the contractile mechanism by PGE2 supported the suggestion that PGE2 have an inhibitory action on Ca2+ influx and Ca2+ release from intracellular Ca store.
通过记录等长张力的变化，研究了前列腺素对人及大鼠离体子宫肌条或阴道条收缩活动的影响。前列腺素E2降低了非孕人子宫体和宫颈的收缩力，但增加了足月人子宫体的收缩力，并降低了足月人子宫颈的收缩力。前列腺素F2α增加了非孕和足月人子宫体和宫颈的收缩力。前列腺素E2增加了非孕和足月大鼠子宫体的收缩力，但降低了非孕和足月大鼠子宫颈和阴道的收缩力。前列腺素F2α增加了非孕和足月大鼠子宫体、宫颈和阴道的收缩力。研究了前列腺素对非孕大鼠去极化子宫平滑肌细胞内钙库的影响。前列腺素对收缩机制的激活作用支持了前列腺素对细胞外钙内流和细胞内钙库释放钙具有激活作用的观点。前列腺素E2对收缩机制的抑制作用支持了前列腺素E2对细胞外钙内流和细胞内钙库释放钙具有抑制作用的观点。
