Li Juan, Wang Shu, Ma Chaoping, Ning Ning, Huang Yingying, Jiao Min, Zhang Jiyuan, Sun Wenwu, Li Jiaoyan, Zhao Bing, Mao Enqiang, Che Zaiqian, Gao Chengjin
Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Department of Intensive Care Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400016, People's Republic of China.
J Inflamm Res. 2024 Aug 30;17:5889-5899. doi: 10.2147/JIR.S467424. eCollection 2024.
New-onset atrial fibrillation (NOAF) and sepsis-induced coagulopathy (SIC) are severe complications in septic patients. However, the relationship between NOAF and SIC score has not been clearly defined. This study aims to investigate the association between SIC score and NOAF, as well as their effect on mortality in sepsis.
This study was a two-center retrospective analysis. Medical data were collected from patients diagnosed with sepsis. The patients were divided into NOAF and non-NOAF groups, and the SIC score was calculated for each group. Univariable and multivariable logistic regression analyses were performed to explore the relationship between the SIC score and NOAF, as well as their effects on mortality. The Kaplan-Meier curve was used to assess the survival rate.
A total of 2,280 septic patients were included, with 132 (5.7%) suffering from NOAF. Multivariable logistic regression analyses indicated that age, gender, the Acute Physiology and Chronic Health Evaluation II score (APACHE II), heart rate, renal failure, stroke, chronic obstructive pulmonary disease (COPD), and the SIC score were independent risk factors for NOAF in sepsis. Moreover, NOAF was associated with an increased risk of in-hospital mortality, 28-day mortality, and 90-day mortality. These results were consistent across subgroup analyses.
The SIC score was an independent risk factor for NOAF in septic patients, and NOAF was an independent risk factor for predicting mortality.
新发房颤（NOAF）和脓毒症诱导的凝血病（SIC）是脓毒症患者的严重并发症。然而，NOAF与SIC评分之间的关系尚未明确界定。本研究旨在探讨SIC评分与NOAF之间的关联，以及它们对脓毒症患者死亡率的影响。
本研究为两中心回顾性分析。收集诊断为脓毒症患者的医疗数据。将患者分为NOAF组和非NOAF组，并计算每组的SIC评分。进行单变量和多变量逻辑回归分析，以探讨SIC评分与NOAF之间的关系及其对死亡率的影响。采用Kaplan-Meier曲线评估生存率。
共纳入2280例脓毒症患者，其中132例（5.7%）患有NOAF。多变量逻辑回归分析表明，年龄、性别、急性生理与慢性健康状况评分系统II（APACHE II）、心率、肾衰竭、中风、慢性阻塞性肺疾病（COPD）和SIC评分是脓毒症患者发生NOAF的独立危险因素。此外，NOAF与住院死亡率、28天死亡率和90天死亡率增加的风险相关。这些结果在亚组分析中是一致的。
SIC评分是脓毒症患者发生NOAF的独立危险因素，而NOAF是预测死亡率的独立危险因素。
