Sugiyama Tomoyasu
School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Cell Insight. 2024 Aug 5;3(5):100194. doi: 10.1016/j.cellin.2024.100194. eCollection 2024 Oct.
Decades have passed since the initial discovery of membrane-less nuclear compartments, commonly called nuclear bodies or nuclear condensates. These compartments have drawn attention to their unique characteristics and functions, especially after introducing "liquid-liquid phase separation" to this research field. While the majority of the studies on nuclear condensates have been conducted in multicellular organisms, recent genetic, biochemical, and cell biological analyses using the fission yeast have yielded valuable insights into biomolecular condensates. This review article focuses on two 'classic' nuclear condensates and discusses how research using fission yeast has unveiled previously unknown functions of these known nuclear bodies.
自从首次发现无膜核区室（通常称为核体或核凝聚物）以来，几十年已经过去了。这些区室因其独特的特征和功能而受到关注，尤其是在将“液-液相分离”引入该研究领域之后。虽然大多数关于核凝聚物的研究是在多细胞生物中进行的，但最近使用裂殖酵母进行的遗传、生化和细胞生物学分析，为生物分子凝聚物提供了有价值的见解。这篇综述文章聚焦于两种“经典”核凝聚物，并讨论了使用裂殖酵母的研究如何揭示了这些已知核体以前未知的功能。
