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美国临床分离株（2019 - 2021年）中对常见口服抗生素的高不敏感性率

High Rates of Nonsusceptibility to Common Oral Antibiotics in Clinical Isolates From the United States (2019-2021).

作者信息

Deshpande Lalitagauri M, Huband Michael D, Charbon Sarah, Castanheira Mariana, Mendes Rodrigo E

机构信息

Element Iowa City (JMI Laboratories), North Liberty, Iowa, USA.

出版信息

Open Forum Infect Dis. 2024 Aug 22;11(9):ofae470. doi: 10.1093/ofid/ofae470. eCollection 2024 Sep.

DOI:10.1093/ofid/ofae470
PMID:39229287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11370784/
Abstract

isolates from the United States (n = 1038; 2019-2021) were susceptible to omadacycline (99.8%), levofloxacin (99.7%), and ceftriaxone (98.1%), whereas doxycycline (80.2%), oral penicillin (63.5%), cefpodoxime (76.8%), and azithromycin (54.4%) activity was limited. (M) did not affect omadacycline activity but altered activity of older tetracyclines including doxycycline, suggesting omadacycline is an important option for treatment of community-acquired bacterial pneumonia.

摘要

来自美国的分离株（n = 1038；2019 - 2021年）对奥马环素（99.8%）、左氧氟沙星（99.7%）和头孢曲松（98.1%）敏感，而多西环素（80.2%）、口服青霉素（63.5%）、头孢泊肟（76.8%）和阿奇霉素（54.4%）的活性有限。（M）不影响奥马环素的活性，但改变了包括多西环素在内的 older tetracyclines 的活性，提示奥马环素是治疗社区获得性细菌性肺炎的重要选择。 （注：原文中“older tetracyclines”表述有误，推测可能是“老一代四环素类药物”，这里按原文翻译）

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