Prusty Priyambada, Jeganmohan Masilamani
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Chem Commun (Camb). 2024 Sep 20;60(76):10540-10543. doi: 10.1039/d4cc03877k.
A cobalt-catalyzed three-component assembly of substituted aryl oximes with dienes and formaldehyde C-H bond activation is described. This protocol affords highly regio- and chemoselective substituted homoallylic alcohols with moderate-to-excellent yields. The scope of this protocol has been extensively explored with various substituted aryl ketoximes and aldoximes. Butadiene and internally substituted dienes are also well compatible for this transformation. A plausible reaction mechanism is proposed to account for the present reaction and is supported by deuterium labeling studies.
描述了一种钴催化的取代芳基肟与二烯和甲醛的三组分组装C-H键活化反应。该方法能以中等到优异的产率提供高度区域和化学选择性的取代高烯丙醇。已使用各种取代的芳基酮肟和醛肟广泛探索了该方法的适用范围。丁二烯和内取代二烯也非常适合这种转化。提出了一种合理的反应机理来解释当前反应，并得到氘标记研究的支持。
