Akiyama Tomoki, Iwazu Yoshitaka, Usui Joichi, Ebihara Itaru, Ishizu Takashi, Kobayashi Masaki, Maeda Yoshitaka, Kobayashi Hiroaki, Yamagata Kunihiro, Kuro-O Makoto
Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Ther Apher Dial. 2025 Apr;29(2):178-188. doi: 10.1111/1744-9987.14203. Epub 2024 Sep 4.
Recent studies have identified increased blood calciprotein particle (CPP) levels as risk factors for vascular calcification and cardiovascular events in patients undergoing maintenance hemodialysis. Although positively correlated with serum phosphate levels, serum CPP levels vary considerably among patients with similar serum phosphate levels. We investigated the capacity of the ratio of serum CPP levels to serum phosphate levels (CPP/Pi ratio) to predict cardiovascular events in incident hemodialysis patients compared to the serum calcification propensity test (T).
The association between the CPP/Pi ratio and major adverse cardiac and cerebrovascular events (MACCE) was investigated in 174 incident hemodialysis patients. Multivariate analysis revealed that the CPP/Pi ratio was independently associated with MACCE [hazard ratio 1.60, 95% confidence interval (1.15-2.23), p = 0.006] but serum T levels were not.
The CPP/Pi ratio is a useful, novel biomarker for predicting the risk of cardiovascular events in patients undergoing incident hemodialysis.
最近的研究已确定血液中钙蛋白颗粒（CPP）水平升高是维持性血液透析患者血管钙化和心血管事件的危险因素。尽管血清CPP水平与血清磷酸盐水平呈正相关，但在血清磷酸盐水平相似的患者中，血清CPP水平差异很大。我们研究了血清CPP水平与血清磷酸盐水平之比（CPP/ Pi比值）相较于血清钙化倾向试验（T）预测新发血液透析患者心血管事件的能力。
在174例新发血液透析患者中研究了CPP/ Pi比值与主要不良心脑血管事件（MACCE）之间的关联。多变量分析显示，CPP/ Pi比值与MACCE独立相关[风险比1.60，95%置信区间（1.15 - 2.23），p = 0.006]，而血清T水平则不然。
CPP/ Pi比值是预测新发血液透析患者心血管事件风险的一种有用的新型生物标志物。
