Centro Universitário Arthur Sá Earp Neto/Faculdade de Medicina de Petrópolis (UNIFASE/FMP).
University of Andrés Bello, School of Dentistry (Santiago, Chile).
Dental Press J Orthod. 2024 Sep 2;29(4):e24spe4. doi: 10.1590/2177-6709.29.4.e24spe4. eCollection 2024.
INTRODUCTION: Osteoarthritis (OA) is a progressive degenerative disease characterized by the gradual degradation of cartilage, remodeling of subchondral bone, synovitis, and chronic pain. This condition impacts various large and small joints, including the temporomandibular joint (TMJ). However, addressing OA, particularly in impeding or reducing disease progression, is challenging due to its clinical and imaging heterogeneity. Authors are increasingly suggesting that this heterogeneity involves different phenotypes or subpopulations, discernible by variations in the disease's pathophysiology and structural manifestations. Even within the TMJ, these phenotypes may display distinct clinical features, laboratory parameters, biochemical markers, and imaging criteria. Recent research has proposed MRI as a reference standard for TMJ OA, highlighting its substantial agreement with histopathological changes. MRI-based phenotypes offer a promising avenue for understanding disease progression and treatment response, potentially providing valuable insights for prognosis and treatment planning. OBJECTIVE: This article introduces the ROAMES-TMJ (Rapid OsteoArthritis MRI Eligibility Score for TMJ) to assess the structural eligibility of individuals for inclusion in TMJ OA clinical trials.
简介:骨关节炎(OA)是一种渐进性退行性疾病,其特征为软骨逐渐退化、软骨下骨重塑、滑膜炎和慢性疼痛。这种疾病影响各种大、小关节,包括颞下颌关节(TMJ)。然而,由于其临床表现和影像学的异质性,OA 的治疗,尤其是对疾病进展的预防或减缓,具有挑战性。作者越来越认为,这种异质性涉及不同的表型或亚群,可以通过疾病的病理生理学和结构表现的差异来识别。即使在 TMJ 中,这些表型也可能表现出不同的临床特征、实验室参数、生化标志物和影像学标准。最近的研究提出了 MRI 作为 TMJ OA 的参考标准,强调了其与组织病理学变化的高度一致性。基于 MRI 的表型为理解疾病进展和治疗反应提供了一个很有前途的途径,可能为预后和治疗计划提供有价值的见解。 目的:本文引入了 ROAMES-TMJ(TMJ 快速骨关节炎 MRI 入选评分),以评估个体纳入 TMJ OA 临床试验的结构入选资格。
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