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揭示磁共振成像(MRI)在颞下颌关节骨关节炎中的结构表型:对临床实践和研究的启示。

Unveiling MRI-based structural phenotypes in temporomandibular joint osteoarthritis: implications for clinical practice and research.

机构信息

Centro Universitário Arthur Sá Earp Neto/Faculdade de Medicina de Petrópolis (UNIFASE/FMP).

University of Andrés Bello, School of Dentistry (Santiago, Chile).

出版信息

Dental Press J Orthod. 2024 Sep 2;29(4):e24spe4. doi: 10.1590/2177-6709.29.4.e24spe4. eCollection 2024.


DOI:10.1590/2177-6709.29.4.e24spe4
PMID:39230116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11368237/
Abstract

INTRODUCTION: Osteoarthritis (OA) is a progressive degenerative disease characterized by the gradual degradation of cartilage, remodeling of subchondral bone, synovitis, and chronic pain. This condition impacts various large and small joints, including the temporomandibular joint (TMJ). However, addressing OA, particularly in impeding or reducing disease progression, is challenging due to its clinical and imaging heterogeneity. Authors are increasingly suggesting that this heterogeneity involves different phenotypes or subpopulations, discernible by variations in the disease's pathophysiology and structural manifestations. Even within the TMJ, these phenotypes may display distinct clinical features, laboratory parameters, biochemical markers, and imaging criteria. Recent research has proposed MRI as a reference standard for TMJ OA, highlighting its substantial agreement with histopathological changes. MRI-based phenotypes offer a promising avenue for understanding disease progression and treatment response, potentially providing valuable insights for prognosis and treatment planning. OBJECTIVE: This article introduces the ROAMES-TMJ (Rapid OsteoArthritis MRI Eligibility Score for TMJ) to assess the structural eligibility of individuals for inclusion in TMJ OA clinical trials.

摘要

简介:骨关节炎(OA)是一种渐进性退行性疾病,其特征为软骨逐渐退化、软骨下骨重塑、滑膜炎和慢性疼痛。这种疾病影响各种大、小关节,包括颞下颌关节(TMJ)。然而,由于其临床表现和影像学的异质性,OA 的治疗,尤其是对疾病进展的预防或减缓,具有挑战性。作者越来越认为,这种异质性涉及不同的表型或亚群,可以通过疾病的病理生理学和结构表现的差异来识别。即使在 TMJ 中,这些表型也可能表现出不同的临床特征、实验室参数、生化标志物和影像学标准。最近的研究提出了 MRI 作为 TMJ OA 的参考标准,强调了其与组织病理学变化的高度一致性。基于 MRI 的表型为理解疾病进展和治疗反应提供了一个很有前途的途径,可能为预后和治疗计划提供有价值的见解。 目的:本文引入了 ROAMES-TMJ(TMJ 快速骨关节炎 MRI 入选评分),以评估个体纳入 TMJ OA 临床试验的结构入选资格。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/a62b6c2f5c10/2177-6709-dpjo-29-04-e24spe4-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/890d962baa39/2177-6709-dpjo-29-04-e24spe4-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/2a76f0fc21c0/2177-6709-dpjo-29-04-e24spe4-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/42368cdeab0a/2177-6709-dpjo-29-04-e24spe4-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/da69aedf305f/2177-6709-dpjo-29-04-e24spe4-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/a62b6c2f5c10/2177-6709-dpjo-29-04-e24spe4-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/890d962baa39/2177-6709-dpjo-29-04-e24spe4-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/2a76f0fc21c0/2177-6709-dpjo-29-04-e24spe4-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/42368cdeab0a/2177-6709-dpjo-29-04-e24spe4-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/da69aedf305f/2177-6709-dpjo-29-04-e24spe4-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db6e/11368237/a62b6c2f5c10/2177-6709-dpjo-29-04-e24spe4-gf5.jpg

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Unveiling MRI-based structural phenotypes in temporomandibular joint osteoarthritis: implications for clinical practice and research.

Dental Press J Orthod. 2024

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[7]
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[8]
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引用本文的文献

[1]
Intra-articular and intraosseous approach to temporomandibular joint-targeted injections: a cadaveric investigation.

J Ultrasound. 2024-12

本文引用的文献

[1]
Histopathological Interpretation of TMJ Osteophyte: Report and Review.

J Maxillofac Oral Surg. 2023-12

[2]
Pharmacological Treatments of Temporomandibular Disorders: A Systematic Review Including a Network Meta-Analysis.

Drugs. 2024-1

[3]
Assessment of temporomandibular joint bone changes associated with anterior disc displacement: An MRI cross-sectional study.

J Stomatol Oral Maxillofac Surg. 2023-12

[4]
Platelet-rich plasma therapy for temporomandibular joint osteoarthritis: A randomized controlled trial.

J Craniomaxillofac Surg. 2023-11

[5]
Hyaluronic acid injections for pain relief and functional improvement in patients with temporomandibular disorders: An umbrella review of systematic reviews.

J Oral Rehabil. 2023-12

[6]
The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.

J Pain. 2023-12

[7]
Reconstructed magnetic resonance image-based effusion volume assessment for temporomandibular joint arthralgia.

J Oral Rehabil. 2023-11

[8]
Imaging signs of temporomandibular joint osteoarthritis in an urban population of 65-year-olds: A cone beam computed tomography study.

J Oral Rehabil. 2023-11

[9]
Platelet-rich plasma injections for the treatment of temporomandibular joint disorders: A systematic review.

J Oral Rehabil. 2023-11

[10]
Intra-articular injections in the TMJ inferior joint space: A scoping review.

J Oral Rehabil. 2023-11

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