Alanya Alaaddin Keykubat University, Faculty of Medical, Department of Emergency - Alanya, Turkey.
Atatürk University, Faculty of Medicine, Department of Emergency Medicine - Erzurum, Turkey.
Rev Assoc Med Bras (1992). 2024 Sep 2;70(8):e20240155. doi: 10.1590/1806-9282.20240155. eCollection 2024.
The aim of this study was to investigate whether there is a difference in serum nitric oxide levels between patients who return spontaneously after cardiopulmonary resuscitation and those who do not. We also examined the potential of using serum nitric oxide levels as a marker to make an accurate decision about patient survival.
We included 100 consecutive patients who were brought to the emergency clinic due to cardiac arrest. Blood samples were taken from these patients at admission, 30 min after admission, and when resuscitation was terminated.
We found that there was a significant difference in NO1 and NO3 values between the group of patients who did not return after cardiopulmonary resuscitation and the group in which spontaneous circulation returned. The NO1 value was significant in the receiver operating characteristic (ROC) analysis, while the NO3 value was not. A higher NO1 value provided a higher rate of survival.
Our findings suggest that nitric oxide may be a useful parameter to support the decision about patient survival. A higher NO1 value is associated with a better prognosis and survival rate. Therefore, serum nitric oxide levels may be a suitable indicator to support the decision-making process regarding patient survival.
本研究旨在探讨心肺复苏后自主循环恢复的患者与未恢复的患者之间血清一氧化氮水平是否存在差异。我们还研究了使用血清一氧化氮水平作为标记物来准确判断患者生存的可能性。
我们纳入了 100 例因心脏骤停而被送往急诊的连续患者。这些患者在入院时、入院后 30 分钟和复苏终止时采集血样。
我们发现，心肺复苏后未恢复自主循环的患者与自主循环恢复的患者之间，NO1 和 NO3 值存在显著差异。NO1 值在受试者工作特征（ROC）分析中具有显著意义，而 NO3 值则没有。较高的 NO1 值提供了更高的生存率。
我们的研究结果表明，一氧化氮可能是支持患者生存决策的有用参数。较高的 NO1 值与更好的预后和生存率相关。因此，血清一氧化氮水平可能是支持患者生存决策的合适指标。
