Beitins I Z, Barkan A, Klibanski A, Kyung N, Reppert S M, Badger T M, Veldhuis J, McArthur J W
J Clin Endocrinol Metab. 1985 Jun;60(6):1120-6. doi: 10.1210/jcem-60-6-1120.
Urinary excretion of gonadotropins increases during fasting. We investigated whether this increase results from increased pituitary secretion of LH and FSH or from altered renal excretion of protein molecules. To this end, we studied urinary gonadotropin excretion, serum gonadotropin levels, and pituitary responsiveness of LHRH during control, 10-day fasting, and refeeding periods in 10 mildly obese postmenopausal women. Additionally, we measured urinary cortisol and estriol excretion and circulating levels of dehydroepiandrosterone sulfate, estradiol, estrone, melatonin, norepinephrine, epinephrine, and dopamine during the control, fasting, and refeeding periods. While urinary excretion of gonadotropins increased markedly during fasting, there were no significant changes in serum gonadotropin levels or in the pituitary sensitivity to LHRH. Plasma norepinephrine and serum melatonin increased significantly during fasting, but serum and urinary estrogens, indices of adrenal activity, and plasma levels of epinephrine and dopamine did not change. These results show that the stress of short term fasting selectively activates only certain components of the neuroendocrine system without any appreciable changes in the function of the gonadotropin-secreting system. Fasting-induced gonadotropinuria is probably explained by altered renal handling of gonadotropin molecules.
禁食期间促性腺激素的尿排泄量会增加。我们研究了这种增加是由于垂体促黄体生成素（LH）和促卵泡生成素（FSH）分泌增加，还是由于蛋白质分子的肾脏排泄改变所致。为此，我们在10名轻度肥胖的绝经后女性的对照期、禁食10天期间和重新进食期，研究了尿促性腺激素排泄、血清促性腺激素水平以及促性腺激素释放激素（LHRH）的垂体反应性。此外，我们还在对照期、禁食期和重新进食期测量了尿皮质醇和雌三醇排泄以及硫酸脱氢表雄酮、雌二醇、雌酮、褪黑素、去甲肾上腺素、肾上腺素和多巴胺的循环水平。虽然禁食期间促性腺激素的尿排泄量显著增加，但血清促性腺激素水平或垂体对LHRH的敏感性没有显著变化。禁食期间血浆去甲肾上腺素和血清褪黑素显著增加，但血清和尿雌激素、肾上腺活动指标以及肾上腺素和多巴胺的血浆水平没有变化。这些结果表明，短期禁食的应激仅选择性激活神经内分泌系统的某些成分，而促性腺激素分泌系统的功能没有任何明显变化。禁食诱导的促性腺激素尿症可能是由于促性腺激素分子的肾脏处理改变所致。
