α-突触核蛋白组学的进展：探索分析技术及其在帕金森病中的临床意义。

ADVANCEMENT IN ALPHA-SYNUCLEIN PROTEOMICS: EXPLORING ANALYTICAL TECHNIQUES AND THEIR CLINICAL IMPLICATIONS IN PARKINSON'S DISEASE.

机构信息

1R&D Laboratory, Department of Chemistry, Excel Engineering College (Autonomous), Namakkal - 637 303, Tamil Nadu, India; 2CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, No-457 Zhongshan Road, Dalian - 116 023, P.R. China.

3R&D Laboratory, Department of Physics, Excel Engineering College (Autonomous), Namakkal - 637 303, Tamil Nadu, India.

出版信息

Georgian Med News. 2024 Jun(351):49-54.

PMID:39230220

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder, affecting around 500,000 to 1 million Americans, with a significant portion diagnosed before age 50. Despite advances in treatments such as dopamine replacement therapy and deep brain stimulation, no therapies currently exist to halt or slow disease progression in advanced stages. Research is increasingly focused on identifying early biomarkers for PD to enable earlier intervention. Alpha-synuclein (α-Syn), a key protein implicated in PD pathology, is studied using various proteomics techniques like mass spectrometry, gel electrophoresis, and chromatography, to understand its role and alterations in PD. These techniques help in extracting, analyzing, and characterizing α-Syn from brain samples, providing insights into disease mechanisms and potential diagnostic and therapeutic applications.

摘要

帕金森病（PD）是一种常见的神经退行性疾病，影响着约 50 万至 100 万美国人，其中相当一部分人在 50 岁之前被诊断出来。尽管多巴胺替代疗法和深部脑刺激等治疗方法有所进展，但目前尚无治疗方法可以阻止或减缓晚期疾病的进展。研究越来越关注识别 PD 的早期生物标志物，以便更早地进行干预。α-突触核蛋白（α-Syn）是一种与 PD 病理有关的关键蛋白，研究人员使用各种蛋白质组学技术，如质谱、凝胶电泳和色谱，来了解其在 PD 中的作用和变化。这些技术有助于从脑样本中提取、分析和鉴定 α-Syn，为疾病机制以及潜在的诊断和治疗应用提供了见解。