肢端肥大症患者选择性腺瘤切除术前及术后的催乳素分泌情况。

Prolactin secretion in acromegalic patients before and after selective adenomectomy.

作者信息

Tsuchiya H, Onishi T, Takamoto S, Imanaka S, Saitoh Y, Mogami H, Mori S, Uozumi T, Kumahara Y

出版信息

J Clin Endocrinol Metab. 1985 Jul;61(1):104-9. doi: 10.1210/jcem-61-1-104.

Abstract

PRL secretion before and after transsphenoidal adenomectomy was studied in 13 patients with acromegaly. Six patient had elevated basal serum PRL levels before surgery, while 7 patients had normal levels. In every patient, the basal serum GH level decreased to less than 5.0 ng/ml after surgery. In the group (group A) with high basal serum PRL levels (mean +/- SD, 41.3 +/- 5.8 ng/ml) before surgery, the PRL levels decreased significantly (P less than 0.0002) to less than 10.0 ng/ml (4.8 +/- 3.6 ng/ml) after the operation. However, in the group (group B) with normal levels (10.8 +/- 4.4 ng/ml) before surgery, PRL levels changed little (7.8 +/- 3.1 ng/ml) after the operation. In group A, the increment of PRL after TRH injection decreased or disappeared (P less than 0.02; 4.1 +/- 2.4 ng/ml) after surgery compared with that before surgery (39.2 +/- 25.9 ng/ml). On the other hand, in group B, the increment of PRL after TRH injection was nearly unchanged (17.1 +/- 7.0 ng/ml) after surgery compared with that before surgery (19.3 +/- 8.0 ng/ml). The results indicate that PRL is secreted from the pituitary adenoma in acromegalic patients with hyperprolactinemia, while PRL secretion from the normal part of the pituitary gland is decreased.

摘要

对13例肢端肥大症患者经蝶窦腺瘤切除术前及术后的催乳素（PRL）分泌情况进行了研究。6例患者术前基础血清PRL水平升高，而7例患者水平正常。每位患者术后基础血清生长激素（GH）水平均降至5.0 ng/ml以下。术前基础血清PRL水平较高（平均±标准差，41.3±5.8 ng/ml）的组（A组），术后PRL水平显著下降（P<0.0002）至10.0 ng/ml以下（4.8±3.6 ng/ml）。然而，术前水平正常（10.8±4.4 ng/ml）的组（B组），术后PRL水平变化不大（7.8±3.1 ng/ml）。在A组中，与术前（39.2±25.9 ng/ml）相比，促甲状腺激素释放激素（TRH）注射后PRL的增量在术后减少或消失（P<0.02；4.1±2.4 ng/ml）。另一方面，在B组中，与术前（19.3±8.0 ng/ml）相比，TRH注射后PRL的增量在术后几乎没有变化（17.1±7.0 ng/ml）。结果表明，高催乳素血症的肢端肥大症患者的PRL由垂体腺瘤分泌，而垂体正常部分的PRL分泌减少。