Tsuchiya H, Onishi T, Takamoto S, Imanaka S, Saitoh Y, Mogami H, Mori S, Uozumi T, Kumahara Y
J Clin Endocrinol Metab. 1985 Jul;61(1):104-9. doi: 10.1210/jcem-61-1-104.
PRL secretion before and after transsphenoidal adenomectomy was studied in 13 patients with acromegaly. Six patient had elevated basal serum PRL levels before surgery, while 7 patients had normal levels. In every patient, the basal serum GH level decreased to less than 5.0 ng/ml after surgery. In the group (group A) with high basal serum PRL levels (mean +/- SD, 41.3 +/- 5.8 ng/ml) before surgery, the PRL levels decreased significantly (P less than 0.0002) to less than 10.0 ng/ml (4.8 +/- 3.6 ng/ml) after the operation. However, in the group (group B) with normal levels (10.8 +/- 4.4 ng/ml) before surgery, PRL levels changed little (7.8 +/- 3.1 ng/ml) after the operation. In group A, the increment of PRL after TRH injection decreased or disappeared (P less than 0.02; 4.1 +/- 2.4 ng/ml) after surgery compared with that before surgery (39.2 +/- 25.9 ng/ml). On the other hand, in group B, the increment of PRL after TRH injection was nearly unchanged (17.1 +/- 7.0 ng/ml) after surgery compared with that before surgery (19.3 +/- 8.0 ng/ml). The results indicate that PRL is secreted from the pituitary adenoma in acromegalic patients with hyperprolactinemia, while PRL secretion from the normal part of the pituitary gland is decreased.
对13例肢端肥大症患者经蝶窦腺瘤切除术前及术后的催乳素（PRL）分泌情况进行了研究。6例患者术前基础血清PRL水平升高，而7例患者水平正常。每位患者术后基础血清生长激素（GH）水平均降至5.0 ng/ml以下。术前基础血清PRL水平较高（平均±标准差，41.3±5.8 ng/ml）的组（A组），术后PRL水平显著下降（P<0.0002）至10.0 ng/ml以下（4.8±3.6 ng/ml）。然而，术前水平正常（10.8±4.4 ng/ml）的组（B组），术后PRL水平变化不大（7.8±3.1 ng/ml）。在A组中，与术前（39.2±25.9 ng/ml）相比，促甲状腺激素释放激素（TRH）注射后PRL的增量在术后减少或消失（P<0.02；4.1±2.4 ng/ml）。另一方面，在B组中，与术前（19.3±8.0 ng/ml）相比，TRH注射后PRL的增量在术后几乎没有变化（17.1±7.0 ng/ml）。结果表明，高催乳素血症的肢端肥大症患者的PRL由垂体腺瘤分泌，而垂体正常部分的PRL分泌减少。
