Tao Ran, Han Katie, Wu Stephanie C, Friske Jake D, Roussel Martine F, Northcott Paul A
Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Genes Dev. 2025 Jan 7;39(1-2):4-17. doi: 10.1101/gad.351936.124.
Medulloblastoma is a heterogeneous embryonal tumor of the cerebellum comprised of four distinct molecular subgroups that differ in their developmental origins, genomic landscapes, clinical presentation, and survival. Recent characterization of the human fetal cerebellum at single-cell resolution has propelled unprecedented insights into the cellular origins of medulloblastoma subgroups, including those underlying previously elusive groups 3 and 4. In this review, the molecular pathogenesis of medulloblastoma is examined through the lens of cerebellar development. In addition, we discuss how enhanced understanding of medulloblastoma origins has the potential to refine disease modeling for the advancement of treatment and outcomes.
髓母细胞瘤是一种小脑的异质性胚胎肿瘤，由四个不同的分子亚组组成，这些亚组在发育起源、基因组格局、临床表现和生存率方面存在差异。最近以单细胞分辨率对人类胎儿小脑的特征描述，为髓母细胞瘤亚组的细胞起源带来了前所未有的见解，包括那些构成先前难以捉摸的3组和4组的细胞起源。在这篇综述中，我们从小脑发育的角度审视了髓母细胞瘤的分子发病机制。此外，我们还讨论了对髓母细胞瘤起源的深入理解如何有可能改进疾病模型，以推动治疗和改善预后。
