Miller Darby D, Wagner Isabella V, Hasan Syed A, Stewart Michael W, Towne Caleb M, Li Zhuo, Baratz Keith H
Departments of Ophthalmology; and.
Quantitative Health Science, Mayo Clinic, Jacksonville, FL; and.
Cornea. 2025 Mar 1;44(3):311-323. doi: 10.1097/ICO.0000000000003694. Epub 2024 Sep 4.
The purpose of this study was to evaluate and compare the anatomic characteristics of eyes with Fuchs endothelial corneal dystrophy (FECD) with eyes without FECD.
This study was a retrospective chart review performed at an academic medical center. Patients with FECD were identified through a search of the electronic medical records. Eligible patients underwent Scheimpflug imaging and optical biometry and were compared with age and sex-matched control subjects who underwent similar testing in preparation for cataract surgery. Several measurements of the cornea, anterior chamber, and eyes were evaluated using multivariable linear regression models and multivariable logistic regression models.
A total of 404 eyes (202 eyes with FECD and 202 control eyes) were included in this study. Compared with controls, eyes with FECD had shallower AC depths, lower AC volumes, and narrower angles. Conversely, the spherical equivalent before cataract surgery, corneal pachymetry, and corneal volume were higher in eyes with FECD. On Scheimpflug imaging analysis, these anatomical differences were present in FECD eyes with and without corneal edema. After adjusting for sex, these differences remained statistically significant. Shorter axial length was found to be statistically significant in male eyes but not in female eyes with FECD.
This study reports new ocular characteristics in FECD eyes with and without edema. Optical biometry and Scheimpflug imaging established that the anatomic findings in eyes with FECD were not simply due to the larger volume of an edematous cornea but rather unique to eyes with FECD. These findings will provide reliable, normative data for future studies examining surgical, medical, and anatomical factors in FECD.
本研究旨在评估和比较患有富克斯内皮性角膜营养不良（FECD）的眼睛与未患FECD的眼睛的解剖特征。
本研究是在一家学术医疗中心进行的回顾性病历审查。通过检索电子病历识别出患有FECD的患者。符合条件的患者接受了Scheimpflug成像和光学生物测量，并与年龄和性别匹配的对照受试者进行比较，这些对照受试者为准备白内障手术而接受了类似测试。使用多变量线性回归模型和多变量逻辑回归模型评估角膜、前房和眼睛的多项测量指标。
本研究共纳入404只眼睛（202只患有FECD的眼睛和202只对照眼睛）。与对照组相比，患有FECD的眼睛前房深度更浅、前房容积更小、房角更窄。相反，患有FECD的眼睛在白内障手术前的等效球镜度、角膜测厚和角膜容积更高。在Scheimpflug成像分析中，无论有无角膜水肿，FECD眼睛均存在这些解剖差异。在对性别进行调整后，这些差异仍具有统计学意义。发现在患有FECD的男性眼睛中眼轴长度较短具有统计学意义，而在女性眼睛中则不然。
本研究报告了有水肿和无水肿的FECD眼睛的新眼部特征。光学生物测量和Scheimpflug成像证实，患有FECD的眼睛的解剖学发现并非仅仅归因于水肿角膜的更大体积，而是FECD眼睛所特有的。这些发现将为未来研究FECD的手术、医学和解剖学因素提供可靠的规范数据。
