日本犬尿变肾上腺素与肌酐比值的参考区间
Reference intervals for urinary metanephrines to creatinine ratios in dogs in Japan.
作者信息
Nagata Noriyuki, Ikenaka Yoshinori, Sawamura Hiryu, Sasaki Noboru, Takiguchi Mitsuyoshi
机构信息
Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
出版信息
J Vet Med Sci. 2024 Oct 1;86(10):1096-1099. doi: 10.1292/jvms.24-0163. Epub 2024 Sep 3.
The urinary normetanephrine to creatinine ratio (uNMN/Cr) and urinary metanephrine to creatinine ratio (uMN/Cr) are commonly evaluated for the diagnosis of pheochromocytomas (PCC) in dogs. This study aimed to establish reference intervals for uNMN/Cr and uMN/Cr in 56 healthy dogs in Japan and to investigate the effect of urine collection methods on these measurements in 15 non-PCC dogs. The upper limits of reference intervals for uNMN/Cr and uMN/Cr were 124.4 nmol/mmol (90% confidence interval [CI] 107.7-137.0) and 121.1 nmol/mmol (90% CI 102.8-145.1), respectively. Both uNMN/Cr and uMN/Cr were significantly higher when urine was collected in the hospital compared to at home. Several factors, including the method of urine collection, should be considered when utilizing these reference intervals.
尿去甲变肾上腺素与肌酐比值（uNMN/Cr）和尿变肾上腺素与肌酐比值（uMN/Cr）常用于犬嗜铬细胞瘤（PCC）的诊断评估。本研究旨在确定日本56只健康犬的uNMN/Cr和uMN/Cr的参考区间，并调查15只非PCC犬的尿液收集方法对这些测量值的影响。uNMN/Cr和uMN/Cr参考区间的上限分别为124.4 nmol/mmol（90%置信区间[CI] 107.7 - 137.0）和121.1 nmol/mmol（90% CI 102.8 - 145.1）。与在家收集尿液相比，在医院收集尿液时，uNMN/Cr和uMN/Cr均显著更高。在使用这些参考区间时，应考虑包括尿液收集方法在内的几个因素。
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