Flamigni C, Venturoli S, Paradisi R, Fabbri R, Porcu E, Magrini O
J Reprod Med. 1985 Mar;30(3):184-8.
Human urinary FSH (HU-FSH) was administered during 25 treatment cycles to 21 infertile women with polycystic ovary syndrome (PCO) who had failed to conceive in response to clomiphene citrate. HCG was also given in 23 of the cycles. Twenty-two (88%) ovulations occurred, and eight (38.1%) conceptions resulted, two (25%) of which terminated in abortion and six (75.0%) in normal deliveries. No multiple pregnancies occurred. Ten instances (40%) of mild-moderate hyperstimulation also resulted. A spontaneous LH surge was observed in 12 treatment cycles. Ultrasound scanning revealed multiple ovarian follicles developing at various rates. We conclude that HU-FSH is an effective form of treatment for women with PCO. However, the response to exogenous FSH is unpredictable and depends on the stage of development and the number of follicles present prior to stimulation.
在25个治疗周期中，对21名患有多囊卵巢综合征（PCO）且对枸橼酸氯米芬无反应而未能受孕的不孕妇女给予人尿促卵泡素（HU-FSH）。在23个周期中还给予了人绒毛膜促性腺激素（HCG）。发生了22次（88%）排卵，8次（38.1%）受孕，其中2次（25%）以流产告终，6次（75.0%）为正常分娩。未发生多胎妊娠。还出现了10例（40%）轻-中度卵巢过度刺激综合征。在12个治疗周期中观察到自发的促黄体生成素高峰。超声扫描显示多个卵巢卵泡以不同速率发育。我们得出结论，HU-FSH是治疗PCO女性的一种有效治疗方式。然而，对外源性促卵泡素的反应是不可预测的，并且取决于刺激前卵泡的发育阶段和数量。
