Seifer D B, Sandberg E C, Ueland K, Sladen R N
J Reprod Med. 1985 Mar;30(3):225-8.
Many nursing women returning to a full-time job and desiring to continue to breast feed are using oxytocin nasal sprays to facilitate breast emptying during the work day. Very few complications have been reported from its use, and the preparation has been assumed to be innocuous. However, we encountered a nursing mother whose life appears to have been jeopardized by the excessive and unmonitored application of such a spray. The patient was hospitalized for a viral illness and given a large quantity of intravenous fluid. In association with excessive self-administration of an oxytocin nasal spray, she developed severe water intoxication, with hyponatremic encephalopathy and convulsions. During the same hospitalization the patient subsequently developed a Guillain-Barré type of peripheral polyneuritis. The syndrome of inappropriate secretion of antidiuretic hormone has been reported to accompany the neurologic manifestations of the Guillain-Barré syndrome and may have been the cause of the convulsions. However, the temporal associations in this case strongly favor the unmonitored use of the oxytocin nasal spray as etiologic.
许多重返全职工作岗位且希望继续母乳喂养的哺乳期女性，正在使用缩宫素鼻喷雾剂来促进工作日期间的排乳。使用该喷雾剂报告的并发症极少，因此人们认为其制剂是无害的。然而，我们遇到了一位哺乳期母亲，她似乎因过度且无监测地使用这种喷雾剂而危及生命。该患者因病毒感染住院并接受了大量静脉输液。由于自行过量使用缩宫素鼻喷雾剂，她出现了严重的水中毒，伴有低钠血症性脑病和惊厥。在同一住院期间，该患者随后又患上了格林-巴利型周围性多神经炎。据报道，抗利尿激素分泌不当综合征与格林-巴利综合征的神经表现同时出现，可能是惊厥的原因。然而，该病例中的时间关联强烈表明，无监测地使用缩宫素鼻喷雾剂是病因所在。
