Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Psychology, the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China.
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Neuroimage Clin. 2024;43:103666. doi: 10.1016/j.nicl.2024.103666. Epub 2024 Aug 31.
To identify the spatial-temporal pattern variation of whole-brain functional connectivity (FC) during reward processing in melancholic major depressive disorder (MDD) patients, and to determine the clinical correlates of connectomic differences.
61 MDD patients and 32 healthy controls were enrolled into the study. During magnetoencephalography (MEG) scanning, all participants completed the facial emotion recognition task. The MDD patients were further divided into two groups: melancholic (n = 31) and non-melancholic (n = 30), based on the Mini International Neuropsychiatric Interview (M.I.N.I.) assessment. Melancholic symptoms were examined by using the 6-item melancholia subscale from the Hamilton Depression Rating Scale (HAM-D6). The whole-brain orthogonalized power envelope connections in the high-beta band (20-35 Hz) were constructed in each period after the happy emotional stimuli (0-200 ms, 100-300 ms, 200-400 ms, 300-500 ms, and 400-600 ms). Then, the network-based statistic (NBS) was used to determine the specific abnormal connection patterns in melancholic MDD patients.
The NBS identified a sub-network difference at the mid-late period (300-500 ms) in response to happy faces among the three groups (corrected P = 0.035). Then, the post hoc and correlation analyses found five FCs were decreased in melancholic MDD patients and were related to HAM-D6 score, including FCs of left fusiform gyrus-right orbital inferior frontal gyrus (r = -0.52, P < 0.001), left fusiform gyrus-left amygdala (r = -0.26, P = 0.049), left posterior cingulate gyrus-right precuneus (r = -0.32, P = 0.025), left precuneus-right precuneus (r = -0.27, P = 0.049), and left precuneus-left inferior occipital gyrus (r = -0.32, P = 0.025).
In response to happy faces, melancholic MDD patients demonstrated a disrupted functional connective pattern (20-35 Hz, 300-500 ms), which involved brain regions in visual information processing and the limbic system. The aberrant functional connective pattern in reward processing might be a biomarker of melancholic MDD.
在忧郁性重性抑郁障碍（MDD）患者的奖励处理过程中，识别全脑功能连接（FC）的时空模式变化，并确定连接组差异的临床相关性。
纳入 61 名 MDD 患者和 32 名健康对照者进行研究。在脑磁图（MEG）扫描期间，所有参与者均完成面部情绪识别任务。根据 Mini 国际神经精神访谈（MINI）评估，将 MDD 患者进一步分为忧郁性（n=31）和非忧郁性（n=30）两组。使用汉密尔顿抑郁评定量表（HAM-D6）的 6 项忧郁子量表评估忧郁症状。在快乐情绪刺激后（0-200ms、100-350ms、200-400ms、300-500ms 和 400-600ms）的每个时期，构建高频β带（20-35Hz）的全脑正交功率包络连接。然后，使用基于网络的统计（NBS）确定忧郁性 MDD 患者中特定的异常连接模式。
NBS 确定了三组中对快乐面孔的中晚期（300-500ms）反应中的一个亚网络差异（校正 P=0.035）。然后，事后和相关性分析发现，忧郁性 MDD 患者的五组 FC 降低，与 HAM-D6 评分相关，包括左侧梭状回-右侧眶额下回（r=-0.52，P<0.001）、左侧梭状回-左侧杏仁核（r=-0.26，P=0.049）、左侧后扣带回-右侧楔前叶（r=-0.32，P=0.025）、左侧楔前叶-右侧楔前叶（r=-0.27，P=0.049）和左侧楔前叶-左侧下顶叶（r=-0.32，P=0.025）。
对快乐面孔的反应中，忧郁性 MDD 患者表现出功能连接模式的破坏（20-35Hz，300-500ms），涉及视觉信息处理和边缘系统的脑区。奖励处理中异常的功能连接模式可能是忧郁性 MDD 的生物标志物。
