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子宫颈癌患者区域淋巴结中的T淋巴细胞和B淋巴细胞。

T and B lymphocytes of the regional lymph nodes in patients with carcinoma of uterine cervix.

作者信息

Ilyin N V, Dexter L I

出版信息

Neoplasma. 1979;26(4):423-7.

PMID:392325
Abstract

A comparative study of the peripheral blood and the regional lymph nodes lymphocyte subpopulations at 25 patients with carcinoma of uterine cervix was carried out by non-immune rosettes and immunofluorescence methods. The lymph nodes of ten women not affected with any disease, but operated on the occasion of the traumas were investigated as a control. The patients had a significant reduction of the relative amount of T cells and increase of number of B cells in their lymph nodes as compared with the control group. A significant variability of immune indices of the regional lymph nodes as compared to those of peripheral blood was shown. It was pointed out that the presence of the metastases in the regional lymph nodes is one of the possible reasons of this phenomena. The possible significance of the results is discussed.

摘要

采用非免疫玫瑰花结法和免疫荧光法对25例子宫颈癌患者的外周血和区域淋巴结淋巴细胞亚群进行了比较研究。以10例未患任何疾病但因外伤接受手术的女性的淋巴结作为对照进行研究。与对照组相比,患者淋巴结中T细胞相对数量显著减少,B细胞数量增加。结果显示区域淋巴结的免疫指标与外周血相比存在显著差异。指出区域淋巴结中存在转移是这种现象的可能原因之一。并对结果的可能意义进行了讨论。

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T and B lymphocytes of the regional lymph nodes in patients with carcinoma of uterine cervix.子宫颈癌患者区域淋巴结中的T淋巴细胞和B淋巴细胞。
Neoplasma. 1979;26(4):423-7.
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Tumor-infiltrating lymphocytes contain higher numbers of type 1 cytokine expressors and DR+ T cells compared with lymphocytes from tumor draining lymph nodes and peripheral blood in patients with cancer of the uterine cervix.与子宫颈癌患者肿瘤引流淋巴结及外周血中的淋巴细胞相比,肿瘤浸润淋巴细胞含有更多数量的1型细胞因子表达细胞和DR+T细胞。
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