Doctorado en Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
Neurologia (Engl Ed). 2024 Sep;39(7):555-563. doi: 10.1016/j.nrleng.2024.07.002.
The cerebellar response has been studied for years with different models of alteration of other brain structures to understand its complex functioning and its relationship with the rest of the body. Studies in patients with Parkinson's disease (PD) showed that the cerebellar function is modified by deficit of the basal ganglia; which supports the hypothesis that both structures are related anatomically and functionally.
In our study, the ventrolateral striatum (VLS) of the basal ganglia was altered by an electrolytic lesion, in order to produce a similar jaw frequency of jaw tremor movements presented in parkinsonism, thereafter we analyzed the effect of the lesion on the expression of multiunit activity (MUA) of the cerebellum.
We found cerebellar activation during mandibular movements and increment during oral jaw tremor movements. In addition, the amplitude of baseline MUA registered in animals with alteration of the VLS decreased with respect to the intact group.
Accordingly, we conclude that cerebellar changes in MUA may be due to a decrease in the cerebellar inflectional or as a possible compensatory function between cerebellum and basal ganglia.
多年来，人们一直在研究小脑反应，通过改变其他脑结构的不同模型来了解其复杂的功能及其与身体其他部位的关系。在帕金森病（PD）患者的研究中，发现小脑功能受到基底节缺陷的改变；这支持了这两个结构在解剖和功能上都有关联的假设。
在我们的研究中，通过电解损伤改变基底节的腹外侧纹状体（VLS），以产生类似于帕金森病中出现的下颌震颤运动的下颌频率，然后分析损伤对小脑多单位活动（MUA）表达的影响。
我们发现咀嚼运动期间小脑激活，口腔下颌震颤运动期间增加。此外，与完整组相比，VLS 改变的动物的基线 MUA 记录的振幅降低。
因此，我们得出结论，MUA 中小脑的变化可能是由于小脑的弯曲度降低，或者是小脑和基底节之间可能存在代偿功能。
