Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), c/o Campus Internazionale "A.Buzzati-Traverso", Via E. Ramarini, 32, Monterotondo Scalo Rome (RM), 00015, Italy.
Unit of Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, Rome, 00144, Italy.
BMC Med. 2024 Sep 4;22(1):363. doi: 10.1186/s12916-024-03574-x.
Aggressive malignancies, such as pancreatic cancer, are increasingly impacting young, female populations. Our investigation centered on whether the observed trends in cancer incidence were unique to pancreatic cancer or indicative of a broader trend across various cancer types. To delve deeper into this phenomenon, we analyzed cancer incidence trends across different age and sex groups. Furthermore, we explored differences in cancer incidence within specific young subgroups aged 18 to 26 and 27 to 34, to better understand the emerging incidence trend among young individuals.
This study collected cancer incidence data from one of the Surveillance, Epidemiology, and End Results cancer registry databases (SEER22), with 10,183,928 total cases from 2000 to 2020. Data were analyzed through Joinpoint trend analysis approach to evaluate sex- and age-specific trends in cancer incidence. Exposure rates were reported as Average Annual Percentage Changes (AAPCs).
The analysis revealed significant age and sex-specific disparities, particularly among individuals aged 18-26 and 27-34. Pancreatic cancer incidence rates increased more in females aged 18-26 (AAPC, 9.37% [95% CI, 7.36-11.41%]; p < .0001) than in males (4.43% [95% CI, 2.36-6.53%]; p < .0001). Notably, among gender, age, and other malignancies, young females had the highest AAPCs for pancreatic cancer. Additionally, the incidence of gastric cancer, myeloma, and colorectal malignancies also showed higher AAPCs in young females compared to males.
Recognizing emerging risk populations for highly lethal malignancies is crucial for early detection and effective disease management.
侵袭性恶性肿瘤，如胰腺癌，越来越多地影响年轻的女性群体。我们的研究集中在观察到的癌症发病率趋势是否仅适用于胰腺癌，还是表明各种癌症类型存在更广泛的趋势。为了更深入地研究这一现象，我们分析了不同年龄和性别组别的癌症发病率趋势。此外，我们还探讨了特定年轻亚组（18 至 26 岁和 27 至 34 岁）内癌症发病率的差异，以更好地了解年轻人中出现的发病率趋势。
本研究从监测、流行病学和最终结果癌症登记数据库（SEER22）之一收集了癌症发病率数据，其中包括 2000 年至 2020 年的 10183928 例总病例。通过 Joinpoint 趋势分析方法分析数据，以评估癌症发病率的性别和年龄特异性趋势。暴露率以平均年百分比变化（AAPC）报告。
分析显示存在显著的年龄和性别特异性差异，特别是在 18-26 岁和 27-34 岁的个体中。18-26 岁女性的胰腺癌发病率上升幅度大于男性（AAPC，9.37%[95%CI，7.36-11.41%]；p<0.0001）。值得注意的是，在性别、年龄和其他恶性肿瘤中，年轻女性的胰腺癌 AAPC 最高。此外，与男性相比，年轻女性的胃癌、骨髓瘤和结直肠癌发病率也呈现更高的 AAPC。
认识到高度致命恶性肿瘤的新兴风险人群对于早期发现和有效疾病管理至关重要。
