Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Pharmacol Res. 2024 Oct;208:107393. doi: 10.1016/j.phrs.2024.107393. Epub 2024 Sep 2.
Mitochondria are metabolic hub, and act as primary sites for reactive oxygen species (ROS) and metabolites generation. Mitochondrial Ca uptake contributes to Ca storage. Mitochondria-organelle interactions are important for cellular metabolic adaptation, biosynthesis, redox balance, cell fate. Organelle communications are mediated by Ca/ROS signals, vesicle transport and membrane contact sites. The permeability transition pore (PTP) is an unselective channel that provides a release pathway for Ca/ROS, mtDNA and metabolites. F-ATP synthase inhibitory factor 1 (IF1) participates in regulation of PTP opening and is required for the translocation of transcriptional factors c-Myc/PGC1α to mitochondria to stimulate metabolic switch. IF1, a mitochondrial specific protein, has been suggested to regulate other organelles including nucleus, endoplasmic reticulum and lysosomes. IF1 may be able to mediate mitochondria-organelle interactions and cellular physiology through regulation of PTP activity.
线粒体是代谢枢纽，也是活性氧（ROS）和代谢物生成的主要场所。线粒体摄取钙有助于钙储存。线粒体-细胞器相互作用对于细胞代谢适应、生物合成、氧化还原平衡和细胞命运至关重要。细胞器间的通讯是通过 Ca/ROS 信号、囊泡运输和膜接触位点来介导的。通透性转换孔（PTP）是一种非选择性通道，为 Ca/ROS、mtDNA 和代谢物的释放提供途径。F-ATP 合酶抑制因子 1（IF1）参与 PTP 开放的调节，并且对于转录因子 c-Myc/PGC1α向线粒体的易位以刺激代谢转换是必需的。IF1 是一种线粒体特异性蛋白，已被提示可调节包括核、内质网和溶酶体在内的其他细胞器。IF1 可能能够通过调节 PTP 活性来介导线粒体-细胞器相互作用和细胞生理学。
