Ramzan Noor Ul Huda, Shahjahan Khadija, Dhillon Rubaid A, Khan Nimra Tul Ain, Hashmat Muhammad Bilal, Anwer Mian Uman, Ahmed Dawood, Afzal Fazila, Tahir Muhammad Mashhood, Muzaffar Ayesha
Medicine, University Medical and Dental College, Faisalabad, PAK.
Medicine, Faisalabad Medical University, Faisalabad, PAK.
Cureus. 2024 Sep 3;16(9):e68550. doi: 10.7759/cureus.68550. eCollection 2024 Sep.
Metformin is a cornerstone therapy for type 2 diabetes mellitus due to its glucose-lowering efficacy and additional benefits such as reducing cardiovascular mortality. However, accumulating evidence suggests an association between long-term metformin use and vitamin B12 deficiency, which can lead to serious clinical consequences. This review aims to synthesize current knowledge on the pathogenesis, prevalence, clinical implications, and management of metformin-induced vitamin B12 deficiency. Given the significant clinical implications, it is crucial to monitor and manage vitamin B12 levels in patients using metformin. This review emphasizes the importance of early detection and supplementation to prevent adverse outcomes. By analyzing the current evidence, the review aims to inform healthcare professionals about best practices for managing vitamin B12 deficiency in patients on metformin, offering insights to guide future clinical practices and research directions.
二甲双胍因其降糖功效以及降低心血管死亡率等额外益处，成为2型糖尿病的基础治疗药物。然而，越来越多的证据表明长期使用二甲双胍与维生素B12缺乏之间存在关联，这可能导致严重的临床后果。本综述旨在综合当前关于二甲双胍所致维生素B12缺乏的发病机制、患病率、临床意义及管理方面的知识。鉴于其重大的临床意义，监测和管理使用二甲双胍患者的维生素B12水平至关重要。本综述强调早期检测和补充以预防不良后果的重要性。通过分析现有证据，本综述旨在告知医疗保健专业人员关于管理使用二甲双胍患者维生素B12缺乏的最佳实践，为指导未来临床实践和研究方向提供见解。
