From the Department of Family Medicine (Al Saeed, Baraja), King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2021 Feb;42(2):161-165. doi: 10.15537/smj.2021.2.25693.
To assess the presence of vitamin B12 deficiency among metformin users and associated factors in patients with type 2 diabetes mellitus.
An observational cross-sectional study was conducted with 307 diabetic patients in the primary health care centers at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia between October 2017 and January 2018. Face-to-face interviews were conducted with the participants, using a designed checklist.
The prevalence of vitamin B12 deficiency was (3.6%) and the majority of the sample had borderline B12 levels (66.1%). The vitamin B12 deficiency and borderline levels were strongly associated with the dose of metformin. Patients taking doses of metformin more than 1000 mg had lower levels of vitamin B12. The use of multivitamin and vitamin B complex was assessed, and it was found that there was a marked decrease in the prevalence of vitamin B12 deficiency in patients using vitamin B complex containing more than 200 mcg vitamin B12.
Our findings show a low prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin. The majority of the sample had borderline deficiency; therefore, additional investigation and management are required.
评估二甲双胍使用者中维生素 B12 缺乏的存在情况以及 2 型糖尿病患者的相关因素。
这是一项在 2017 年 10 月至 2018 年 1 月期间在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城（KAMC）的基层医疗保健中心进行的观察性横断面研究。使用设计好的检查表对参与者进行了面对面的访谈。
维生素 B12 缺乏的患病率为（3.6%），且大多数样本的 B12 水平处于边缘状态（66.1%）。维生素 B12 缺乏症和边缘水平与二甲双胍的剂量强烈相关。服用剂量超过 1000mg 的二甲双胍的患者的 B12 水平较低。评估了使用多种维生素和维生素 B 复合物的情况，发现使用含有超过 200mcg 维生素 B12 的维生素 B 复合物的患者中，维生素 B12 缺乏症的患病率显著降低。
我们的研究结果表明，服用二甲双胍的 2 型糖尿病患者维生素 B12 缺乏症的患病率较低。大多数样本的维生素 B12 缺乏处于边缘状态，因此需要进一步调查和管理。
